Synthesis of N-1 Substituted Indolylchalcone Hybrids and anti-angiogenic activity evaluation using the Chorioallantoic Membrane (CAM) Assay. According to the findings, N-1 substituted Indolylchalcone hybrids of 2-acetyl benzimidazole could be promising angiogenesis inhibitor analogs for managing uncontrolled neovascularization that occurs during malignant tumor development. The Claisen-Schmidt procedure, which involves condensation of N-1 substituted indole-3-carboxaldehyde and N1 substituted 2-acetylbenzimidazole, was utilized to make 30 Indolylchalcone hybrids. In alkylation and arylation, phase transfer catalysts, green catalysts such as anhydrous potassium carbonate (K2CO3), and PEG-400 are utilized. The antiangiogenic activity of all produced indolylchalcone hybrids was assessed using the in-vivo chorioallantoic membrane (CAM) assay method.
Conclusion: The synthesized Indolylchalcones, as indicated in the graph, have excellent anti-angiogenic properties that are dose dependent. Methyl >Ethyl>Cl-benzyl> Benzyl>Isobutyl>Isobutyl>Isobutyl>Isobutyl>Isobutyl>Isobutyl>Isobutyl>Isobutyl>Isobutyl>Is Analogs of 2-acetyl benzimidazole could be developed into powerful angiogenesis inhibitors in the future.Author (s) Details
Dr. Anjali Mahesh Wanegaonkar
Bharati Vidyapeeth College of Pharmacy, Sector-8, CBD Belapur - Navi Mumbai- 400614, India.
Dr. Milind Jagannathji Bhitre
Department Pharmaceutical Chemistry C. U. Shah College of Pharmacy, S. N. D. T. Women’s University, Sir Vithaldas Vidyavihar, Juhu Road, Santacruz (West) Mumbai- 400 049, India.
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