Coumarins,
a ubiquitous class of natural benzopyrones, are a foundational scaffold in
medicinal chemistry due to their extensive array of biological activities. This
report details the advanced synthetic strategies for generating substituted
coumarins, with a particular focus on the construction of angular and linear
furo- and pyranocoumarin derivatives. Key synthetic transformations discussed
include the Claisen rearrangement, Wittig reaction, selenium dioxide oxidation,
sodium borohydride reduction, Reformatsky reaction, and Grignard reaction. Each
methodology is examined for its specific contribution to the precise formation
and functionalization of these complex heterocyclic systems. The report
emphasises the pharmaceutical importance of angular and linear furo- and
pyranocoumarin derivatives, highlighting their broad-spectrum therapeutic
applications, such as anticancer, anti-inflammatory, antimicrobial, and
neuroprotective effects. It also addresses the critical role of
structure-activity relationships in guiding synthetic design and the ongoing
efforts to overcome challenges like drug resistance and optimising
bioavailability, underscoring the continuous evolution of coumarin chemistry
for therapeutic innovation.
Author(s) Details
Dr. Ranjit Kumar Shit
Department of
Chemistry, Vidyasagar College (Calcutta University), Kolkata, India.
Dr. Nitai Chand Sinha
Department of
Chemistry, Sarat Centenary College (Burdwan University), India.
Please see
the link:- https://doi.org/10.9734/bpi/mono/978-81-991703-9-1
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