Coumarins, a ubiquitous class of natural benzopyrones, are a
foundational scaffold in medicinal chemistry due to their extensive array of
biological activities. This report details the advanced synthetic strategies
for generating substituted coumarins, with a particular focus on the
construction of angular and linear furo- and pyranocoumarin derivatives. Key
synthetic transformations discussed include the Claisen rearrangement, Wittig
reaction, selenium dioxide oxidation, sodium borohydride reduction, Reformatsky
reaction, and Grignard reaction. Each methodology is examined for its specific
contribution to the precise formation and functionalization of these complex
heterocyclic systems. The report emphasises the pharmaceutical importance of
angular and linear furo- and pyranocoumarin derivatives, highlighting their
broad-spectrum therapeutic applications, such as anticancer, anti-inflammatory,
antimicrobial, and neuroprotective effects. It also addresses the critical role
of structure-activity relationships in guiding synthetic design and the ongoing
efforts to overcome challenges like drug resistance and optimising
bioavailability, underscoring the continuous evolution of coumarin chemistry
for therapeutic innovation.
Author(s) Details
Dr. Ranjit Kumar Shit
Department of Chemistry, Vidyasagar College (Calcutta University), Kolkata,
India.
Dr. Nitai Chand Sinha
Department of Chemistry, Sarat Centenary College (Burdwan University),
India.
Please see the book here:- https://doi.org/10.9734/bpi/mono/978-81-991703-9-1
