Numerous microorganisms exhibit the phenomenon known as independent oscillations of species levels in glycolysis, that demonstrates the self-control concerning this crucial cellular road that is any of the central carbon absorption (CCM). Living cells oscillate their levels of glycolytic go-between in response to their surroundings and internal processes, particularly the ATP improvement system. As long as most of the glycolytic go-between are involved in various basic metabolic pathways belonging to the CCM, determining the environments that lead to the incident and maintenance of the glycolytic oscillations, and evaluation of the movement and average level of its intermediates is of extreme importance, by giving immediate practical requests, due to glycolysis connections accompanying most of cell syntheses. Based on our glycolysis energetic model, validated in previous everything, this paper is aiming to in silico (math model-located) identify referring to practices or policies that do not negatively affect the environment conditions and cell determinants leading to the incident of stable glycolytic oscillations in the E. coli cells. Such an reasoning can be used to design genetic reduced micro-organisms (GMO) containing certain ’motifs’ of useful interest. As an example, interactions 'tween the glycolytic oscillations and the oscillatory TRP synthesis (through the PEP (phosphoenolpyruvate) joint node) is here analysed.
The
analysis allows further TRP production maximization in a semi-continuous
bioreactor (SBR).
Author(s) Details:
Gheorghe Maria,
Department of Chemical and Biochemical Engineering, University Politehnica
of Bucharest, Polizu Str. 1-7, Bucharest-011061, Romania and Romanian Academy,
Chemical Sciences Section, Calea Victoriei 125, Bucharest-010071, Romania.
Please see the link here: https://stm.bookpi.org/RAMB-V5/article/view/10480
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