A Systemic Review on Robotic Versus Laparoscopic Adrenalectomy | New Visions in Science and Technology Vol. 5

 Background: Multidrug resistance (MDR) in bacterial infections is becoming increasingly common around the world. To combat this, some ancient medications, such as fosfomycin, are being reintroduced. The goal of our research was to find out if fosfomycin was effective against drug resistance isolates from non-urinary samples. Fosfomycin susceptibility to Pseudomonas aeruginosa was found to be lower in the majority of investigations. The study's goals were to I determine the susceptibility of fosfomycin against Methicillin-Susceptible and Resistant Staphylococcus aureus, ESBL-producing Escherichia coli, Klebsiella species, and Metallo Beta Lactamase-producing Pseudomonas aeruginosa isolated from specimens other than urine, and to assess the agreement between the two methods, disc diffusion and agar

Procedures: The first isolate of each species per patient (n=250) was tested for fosfomycin susceptibility simultaneously using the disc diffusion and agar dilution methods outlined in CLSI guidelines, with a comparison of the two methods.

According to CLSI and EUCAST standards, Staphylococcus aureus and ESBL E. coli showed 100% susceptibility, but ESBL generating Klebsiella species demonstrated 88 percent susceptibility to fosfomycin 200 g/disc and 80 percent and 72 percent by agar dilution technique. According to EUCAST criteria, 90 percent of MBL generating Pseudomonas aeruginosa isolates were sensitive to fosfomycin 200 g/disc and 60 percent (32 g/ml) in agar dilution. For S. aureus and E. coli, the disc diffusion approach showed strong agreement, but only moderate agreement for Klebsiella species and low agreement for Pseudomonas aeruginosa.

Conclusion: Fosfomycin can be used to treat infections caused by multidrug-resistant bacteria, not only in urinary tract infections but also in systemic illnesses. For all common isolates, this can be accomplished by establishing breakpoint values and zone diameter.

Author(S) Details

Premalatha Ethirajulu
Department of Microbiology, Tagore Medical College & Hospital, Affiliated to Tamilnadu DR MGR Medical University, Chennai, India.

Jeyakumari Duraipandian
Department of Microbiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Karaikal, Pondicherry, India.

Kandasamy Sankararaman
Department of Microbiology, Tagore Medical College & Hospital, Affiliated to Tamilnadu DR MGR Medical University, Chennai, India.

Sony Mary Paul
Department of Microbiology, Tagore Medical College & Hospital, Affiliated to Tamilnadu DR MGR Medical University, Chennai, India.

Priestly Vivekkumar
Department of Pharmacology, Tagore Medical College & Hospital, Affiliated to Tamilnadu DR MGR Medical University, Chennai, India.

Sukumar Rathnamgiri
Department of Microbiology, Tagore Medical College & Hospital, Affiliated to Tamilnadu DR MGR Medical University, Chennai, India.

View Book:- https://stm.bookpi.org/RDMMR-V1/article/view/4073