Background: Fixed dosage drug combinations (FDCs) are two or more active drugs combined into a single dose. It should be used when the combination has a confirmed efficacy, safety, and compliance advantage over a single medication. The World Health Organization lists just 19 such combinations (WHO). The Indian market, on the other hand, is inundated with hundreds of unauthorised FDCs, resulting in irrational use. The goal of this study was to determine the fixed dose combination of antimicrobial medicines used in a tertiary care teaching hospital's post-operative general surgery unit. Methods: Prescriptions of patients admitted between April 2013 and March 2014 were evaluated after receiving consent from the institutional human ethics council. Demographic information, surgeon-prescribed FDC, Dose, Frequency, Duration, Route, Formulation, Brand or generic medicines, Adverse effects The events that occurred as a result of the usage of FDC were recorded, and statistical analysis was performed using SPSS version 17. In 90 patients, fixed dosage combinations were used. Ampicillin with Cloxacillin (43) was the most regularly used FDC, followed by amoxicillin with clavulanic acid (22), cefoperazone with sulbactam (19), and piperacillin with tazobactam (6). Metronidazole and aminoglycosides were a common medication used in combination with FDC. Ampicillin plus Cloxacillin (8.88 percent) of the total FDC was the illogical combination seen in this investigation, which is not approved by DCGI or FDA. Results: Of the 145 medications used in this study, 41 were given three times a day, 90 were given twice a day, and 14 were given once a day. FDCs were given to 53 patients for prophylaxis and 37 patients for therapy. All of the FDCs were prescribed under their brand names. In this trial, no adverse medication reactions were reported. Conclusions: Rather than relying on representation, consultants should participate in evidence-based continuing medical education (CME) on novel drug combinations and related adverse drug events.
Author(s) Details
Department of Pharmacology, Aarupadai Veedu Medical College and Hospital, Kirumampakkam, Puducherry- 607402, India.
J. Johan Pandian
Department of Pharmacology, Mahatma Gandhi Medical College & Research Institute, Pillaiyarkuppam, Puducherry 607402, India.
View Book :- https://stm.bookpi.org/TIPR-V9/article/view/2524
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