Tenofovir disoproxil fumarate is a nucleotide reverse transcriptase inhibitor with an extremely bitter taste that is critical for patient compliance when taken orally. At this study, a complexation technique and an oral dispersible tablet formulation including super disintegrant croscarmellose sodium in various dosages were used to try to conceal the bitter taste of Tenofovir Disproxil Fumarate. In the formulation of the combination containing Tenofovir Disproxil Fumarate, the polymer Eudragit L -100 was utilised. The complexes were made in ratios of 1:1, 1:2, and 1:3. The medication The loading technique was optimised using and polymer ratio. The panel method was used to determine taste masking, and FTIR was used to characterise the compounds. Using the optimised drug-polymer complexes, oral dispersible tablets were made and evaluated for pre-formulation and post-formulation characteristics (1:3 ratio). Thickness, hardness, diameter, weight fluctuation, friability, disintegration time, invitro dissolution time, and stability were all assessed on the formulations. All of the parameters pass the test. This breakthrough could lead to the creation of a non-bitter Tenofovir Disoproxil Fumarate dosage form with great bioavailability and stability.
Author(s) Details
Department of Pharmaceutics, P. Wadhwani College of Pharmacy Yavatmal 445001, Sant Gadge Baba Amravati University,Amravati, Maharashtra, India.
Associate Professor Dr. Bharati V. Bakade
Department of Pharmaceutics, P. Wadhwani College of Pharmacy Yavatmal 445001, Sant Gadge Baba Amravati University, Amravati, Maharashtra, India.
Assistant professor Sayali S. Bompelwar
Department of Pharmaceutics, P. Wadhwani College of Pharmacy Yavatmal 445001, Sant Gadge Baba Amravati University, Amravati, Maharashtra, India.
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