Recent Study on Endoplasmic Reticulum Stress (ER Stress) and Unfolded Protein Response (UPR) Occur in a Rat Varicocele Testis Model | Chapter 2 | Highlights on Medicine and Medical Research Vol. 9

Using a surgically produced varicocele rat model, we show that the misfolded/unfolded protein response, which is part of the endoplasmic reticulum (ER) stress response, is activated in the varicocele testis (VCL), leading to apoptotic induction. The spliced variation of the X-box protein 1 (XBP1s), which results from the activation of the inositol-requiring enzyme 1 (IRE1) membrane sensor, is substantially more prevalent in VCL testicular extracts, which supports this notion. The activation of the IRE1/XBP1s pathway is also supported by the fact that the VCL testes have increased phosphorylation of c-Jun-kinase (JNK), which is one of the pathway's intermediates, as well as an increased level of caspase-3, the terminal apoptotic effector, which helps to explain the VCL testis' apoptotic status. The involvement of the IRE1/JNK/XBP1s pathway indicates that the UPR/ER response is most likely active in the VCL testis.

Author (s) Details

Mohammad H. Nasr-Esfahani
Department of Animal Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran.

Erfaneh Shaygannia
Department of Animal Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran.

Mohsen Rahmani
Department of Animal Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran.

Anahita Eskandari
Department of Animal Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran.

Aram Ahmadzadeh Golsefid
Department of Animal Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran.

Marziyeh Tavalaee
Department of Animal Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran.

Parviz Gharagozloo
Celloxess LLC, 830 Bear Tavern Road, Ewing, NJ 08628, USA.

Joël R. Drevet
Université Clermont Auvergne, CNRS, Inserm, GReD, F-63000 Clermont-Ferrand, France.

Mohammad H. Nasr-Esfahani
Department of Animal Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran.

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