Objectives: To
study the levels of cellular hypoxia, apoptosis and the dependence of these
factors on the value of impaired kidney function; to assess the potential
protective effects of tocopherol antioxidant therapy in children with nephrotic
syndrome.
Context: Through the activation of
certain secondary processes, hypoxia-related disorders play an important role
in irreversible tissue damage. Peripheral edema, heavy proteinuria, and
hypoalbuminemia, often with hyperlipidemia, consist of nephrotic syndrome (NS).
Methods: Renal biopsy screening of
53 patients (aged 10-15 years) with nephrotic syndrome. This study used
conventional clinical studies, immunochemistry and immunoblotting.
Results: Children with nephrotic
syndrome have been shown to have a high HIF-1 alpha cellular hypoxia marker.
The latest levels depend on the level of impaired kidney function and
proteinuria. The progression of sclerosis, which is a sign of irreversible
kidney damage, is accompanied by a gradual increase in the expression of the
proapoptotic factor Bax. A conventional system is composed of an applied
treatment and tocopherol showed an improvement in the level of hypoxia,
proapoptotic factor Bax expression.
Conclusion: The application of
antioxidants can attenuate hypoxia-induced disorders in nephrotic children
caused by disorders in the apoptosis control system. In the field of
nephrology, further research into the molecular mechanisms that preserve the
kidney in nephrotic children and non-toxic nephroprotective agents, including
antioxidants, are important issues.
Author (s) Details
Ievgeniia
Burlaka
Department of
Pediatrics №4, Bogomolets National Medical University, №4, Kyiv, Tolstogo
Street 10, 01004, Ukraine.
View Book :- https://stm.bookpi.org/RTCMS-V8/issue/view/3
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