The present study investigated the antihyperglycemic effect
of different fractions of methanol extract of Ceiba pentandra leaves. Chronic hyperglycemia during diabetes
causes glycation of body proteins that in turn leads to secondary complications
affecting e, kidneys, nerves and arteries. Petroleum ether, chloroform, ethyl
acetate and methanol fractions of Ceiba
pentandra leaves were prepared and administered individually at different
doses to different batches of rats (both normal and alloxan diabetic rats)
after an overnight fast. The blood glucose levels were measured at 0, 2, 4 h, 7
and 14 days after the treatment. The antihyperglycemic activity of Ceiba pentandra leaves was compared with
the treatment of glibenclamide, an oral hypoglycemic agent. The results
indicate that C. pentandra possesses significant antihyperglycemic activity.
All fractions except petroleum ether fraction even if with a different degree,
have shown significant reduction in blood glucose levels in alloxan-induced
diabetic rats. The methanol fraction has shown maximum effect in all the two
tests compared to the other extracts. The methanol fraction of Ceiba pentandra at a dosage of 200 mg/kg
body weight shows a maximal blood glucose lowering effect in diabetic rats.
Author(s) Details
A.R. Kharat
Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh-786
004, India and Government College of
Pharmacy, Chhatrapati Sambhajinagar-431005, India.
S. Das
Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh-786
004, India and Department of Pharmaceuitcal Sciences, Assam University,
Silchar-788011, India.
K.R. Kharat
Department of Zoology, Mizoram University, Aizwal-79004, India.
Please see the book here:- https://doi.org/10.9734/bpi/prrat/v4/1117
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