Antihyperglycemic Effect of Different Fractions of Methanol Extract of Ceiba pentandra Leaves | Chapter 4 | Pharmaceutical Research - Recent Advances and Trends Vol. 4

 

The present study investigated the antihyperglycemic effect of different fractions of methanol extract of Ceiba pentandra leaves. Chronic hyperglycemia during diabetes causes glycation of body proteins that in turn leads to secondary complications affecting e, kidneys, nerves and arteries. Petroleum ether, chloroform, ethyl acetate and methanol fractions of Ceiba pentandra leaves were prepared and administered individually at different doses to different batches of rats (both normal and alloxan diabetic rats) after an overnight fast. The blood glucose levels were measured at 0, 2, 4 h, 7 and 14 days after the treatment. The antihyperglycemic activity of Ceiba pentandra leaves was compared with the treatment of glibenclamide, an oral hypoglycemic agent. The results indicate that C. pentandra possesses significant antihyperglycemic activity. All fractions except petroleum ether fraction even if with a different degree, have shown significant reduction in blood glucose levels in alloxan-induced diabetic rats. The methanol fraction has shown maximum effect in all the two tests compared to the other extracts. The methanol fraction of Ceiba pentandra at a dosage of 200 mg/kg body weight shows a maximal blood glucose lowering effect in diabetic rats.

Author(s) Details

A.R. Kharat
Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh-786 004, India and Government College of Pharmacy, Chhatrapati Sambhajinagar-431005, India.

S. Das
Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh-786 004, India and Department of Pharmaceuitcal Sciences, Assam University, Silchar-788011, India.

K.R. Kharat
Department of Zoology, Mizoram University, Aizwal-79004, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/prrat/v4/1117

Investigating the Antihyperglycaemic Effect of Vetiveria zizanioides (L.) Nash Root Extract in Alloxan-induced Diabetic Rats | Chapter 6 | Advanced Concepts in Pharmaceutical Research Vol. 9

 

Vetiveria zizanioides (L.) Nash (family: Poaceae) is commonly known as 'Khas-Khas' in Bangladesh and India. The aim of this study is to evaluate the antihyperglycaemic activity of the ethanol extract of roots of Vetiveria zizanioides (L.) Nash, in alloxan-induced diabetic rats. Wistar albino rats weighing 250- 350 g of both sexes were selected for the present investigation Antihyperglycaemic Effect of Vetiveria zizanioides (L.) Nash Root Extract. Alloxan monohydrate (150 mg/kg) was administered to Wister albino rats via the interperitoneal route. The diabetic rats were then placed into 6 groups, following the stabilization of hyperglycaemia. The first group was untreated; the second group received a reference standard, glibenclamide (10 mg/kg) and the next four groups received ethanol extract of V. zizanioides roots at the doses of 100, 250, 500 and 750 mg/kg, respectively each day. Treatment was provided via the oral route for 28 days and fasting sugar level was monitored over this period. Acute toxicity (oral and interperitoneal) studies as well as phytochemical screenings of the extracts were carried out. It was observed that ethanol extract of V. zizanioides (100, 250, 500 and 750 mg/kg p.w.o) significantly reduced the blood glucose level at the end of 28th days in alloxan-induced diabetes rats. The antihyperglycaemic effects were compared with those of glibenclamide (10 mg/kg p.w.o), the standard reference hypoglycaemic agent. The present study indicates that ethanol extract of V. zizanioides root posses better antihyperglycaemic activity compared to other extracts of it in both normal and alloxan-induced diabetic rats. The study provides proof for the ethnomedical claims and reported biological activities of V. zizanioides with respect to its good therapeutic and antidiabetic potential. We concluded that the ethanolic extract of V. zizanioides has hypoglycaemic and antihyperglycaemic activity as it lowers blood glucose levels in diabetic rats. However, the molecule (s) responsible for such an effect requires further investigation.

Author(s) Details:

Dr. Sanjay Kumar Karan,
Seemanta Institute of Pharmaceutical Sciences, Jharpokharia-757 086, India.

Dilipkumar Pal
School of Pharmaceutical Sciences, IFTM University, Moradabad-244 102, India.

Sagar Kumar Mishra
University Department of Pharmaceutical Sciences, Utkal University, Vanivihar, Bhubaneswar-751 004, India.

Arijit Mondal
Department of Pharmaceutical Technology, Jadavpur University, Kolkata-700 032, India.

Please see the link here: https://stm.bookpi.org/ACPR-V9/article/view/14365

Discovering and Development of Antidiabetic Drugs from Natural Sources: An Essential Dietary Legume in Indian Culture is the Pigeon Pea (Cajanus cajan L.) | Chapter 13 | Current Overview on Pharmaceutical Science Vol. 8

 A off-course variety of subordinate metabolites are produced by plants as a kind of care against environmental stress or added causes like pest infestations, wounds, and injuries. Pulse crops have a long past of being valued for their digestive value and energy-promoting qualities, containing their outstanding protein, fibre, and hydrogen content as well as their ability to control obesity, decrease cholesterol, and forestall type 2 diabetes.In this book chapter, I have discussed about the antihyperglycemic potential of Cajanus cajan leaves indifferent solvent extracts on alloxan-inferred diabetic mice. Among the four financially sound extracts tested, namely oil ether, kill, ethyl acetate, and methanol extract, two extracts, i.e ethyl acetate and flammable liquid extract, lowered level of glucose in blood levels by 27.09 and 37.68%, respectively, in diabetic rodent after daily spoken administration for 10 days at a dosage of 250 mg/kg.  Glibenclamide (0.4mg/kg) reduced blood sugar levels by 30.57% all the while the same situation period. These two extracts also raised insulin action. While insulin unique resulted in a 32.66% decrease in glucose. Blood sugar dropped by 48.14% and 43.07%, respectively, subsequently the extract of methanol and ethyl acetate were executed simultaneously. The extract did not exhibit some fatality or poisonous symptoms at a measure of 2000 mg/kg in an acute toxicity trial (OECD recommendations), and suitable way, C. cajan extracts are regarded as secure. The active fractions' RP-HPLC sketches were completed; these sketches will be useful in the future for recognizing the bioactive elements.

Author(s) Details:

Rupa Sengupta,
Girijananda Chowdhury University, Guwahati, Assam, India.

Please see the link here: https://stm.bookpi.org/COPS-V8/article/view/9874