Vetiveria zizanioides (L.) Nash (family: Poaceae) is
commonly known as 'Khas-Khas' in Bangladesh and India. The aim of this study is
to evaluate the antihyperglycaemic activity of the ethanol extract of roots of
Vetiveria zizanioides (L.) Nash, in alloxan-induced diabetic rats. Wistar
albino rats weighing 250- 350 g of both sexes were selected for the present
investigation Antihyperglycaemic Effect of Vetiveria zizanioides (L.) Nash Root
Extract. Alloxan monohydrate (150 mg/kg) was administered to Wister albino rats
via the interperitoneal route. The diabetic rats were then placed into 6
groups, following the stabilization of hyperglycaemia. The first group was
untreated; the second group received a reference standard, glibenclamide (10
mg/kg) and the next four groups received ethanol extract of V. zizanioides
roots at the doses of 100, 250, 500 and 750 mg/kg, respectively each day.
Treatment was provided via the oral route for 28 days and fasting sugar level
was monitored over this period. Acute toxicity (oral and interperitoneal)
studies as well as phytochemical screenings of the extracts were carried out.
It was observed that ethanol extract of V. zizanioides (100, 250, 500 and 750
mg/kg p.w.o) significantly reduced the blood glucose level at the end of 28th
days in alloxan-induced diabetes rats. The antihyperglycaemic effects were
compared with those of glibenclamide (10 mg/kg p.w.o), the standard reference
hypoglycaemic agent. The present study indicates that ethanol extract of V.
zizanioides root posses better antihyperglycaemic activity compared to other
extracts of it in both normal and alloxan-induced diabetic rats. The study
provides proof for the ethnomedical claims and reported biological activities
of V. zizanioides with respect to its good therapeutic and antidiabetic
potential. We concluded that the ethanolic extract of V. zizanioides has
hypoglycaemic and antihyperglycaemic activity as it lowers blood glucose levels
in diabetic rats. However, the molecule (s) responsible for such an effect
requires further investigation.
Author(s) Details:
Dr. Sanjay Kumar Karan,
Seemanta Institute of Pharmaceutical Sciences, Jharpokharia-757 086,
India.
Dilipkumar Pal
School of Pharmaceutical Sciences, IFTM University, Moradabad-244 102,
India.
Sagar Kumar Mishra
University Department of Pharmaceutical Sciences, Utkal University,
Vanivihar, Bhubaneswar-751 004, India.
Arijit Mondal
Department of Pharmaceutical Technology, Jadavpur University, Kolkata-700
032, India.
Please see the link here: https://stm.bookpi.org/ACPR-V9/article/view/14365
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