In the present study, we have designed and synthesized a new series of bipyrimidines by simple condensation and screened them for their in vitro antimicrobial activities. Current research has depicted the efforts towards the utilization of biphasic reaction systems in the synthesis of a variety of heterocycles. This shows the remarkable importance of the monophasic solvent system. A simple, green and efficient catalytic condensation process has been developed to synthesize the series of 2-amino-6-substituted- 4,6-diphenyl-3’,4,4’,5-tetrahydro[4,5’-bipyrimidine]-2’(1H)-one (3a- j) hybrids. The catalytic route was investigated efficiently in the presence of NaY zeolite in an organic-aqueous (dichloromethane-water) solvent system. In this method, biphasic solvent systems were explored for suitable applicability where catalyst exhibits remarkable reactivity. The synthesized scaffolds of bipyrimidines were studied as anti-microbial agents. The investigation of antimicrobial screening data revealed that among 10 compounds screened, compounds 3d, 3e, 3f and 3i demonstrated very good activity as compared to standard drugs and the remaining compounds showed good to moderate inhibition activities.
Synthesized compounds were screened for their in vitro
antibacterial activity against Staphylococcus aureus, E. coli and Pseudomonas
aurigenosa and also antifungal activity against the opportunistic pathogens
Candida albicans and Aspergillus niger.
Author(s) Details:
Manisha S. Aswale,
Department of Chemistry, Centre for Higher Learning and Research,
Sardar Patel Mahavidyalaya, Ganjward, Chandrapur-442402, India.
Raksha P. Dhankar
Department of Chemistry, Centre for Higher Learning and Research, Sardar
Patel Mahavidyalaya, Ganjward, Chandrapur-442402, India.
Please see the link here: https://doi.org/10.9734/bpi/rdcbr/v3/8227E
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