Iodination of Aromatic Acetamides Derivatives Using Iodine and Iodic Acid under Both Conventional Method and Microwave Irradiation Technique| Chapter 4 | Current Innovations in Chemical and Materials Sciences Vol. 9

 

The aromatic iodination reaction is an important electrophilic substitution reaction and the resultant Iodo products are useful intermediate in organic synthesis. Iodoacetamides were synthesized by iodination using iodine and iodic acid as an iodinating reagent in ethanol under conventional methods as well as microwave irradiation. Microwave technique has several advantages over conventional technique in terms of simple reaction procedure, easy work up and yields of product. The study findings revealed that both conventional and microwave-assisted procedures resulted in the corresponding iodinated compounds with excellent yields and high regioselectivity at the para position. The synthesized Iodo compounds were confirmed by IR, 1H NMR, Mass, and halogen analysis.

Author(s) Details:

Dr. Arvind Patil,
Department of Chemistry, SNJB's K.K.H.A. Arts, S.M.G.L. Commerce & S.P.H.J. Science College, Chandwad. Dist. Nashik. 423101. (M.S.) India.

Sainath Zangade
P.G. Department of Studies in Chemistry, Organic Research Laboratory, Yeshwant Mahavidyalaya, Nanded- 431602 (M.S.), India.

Archana Vibhute
P.G. Department of Studies in Chemistry, Organic Research Laboratory, Yeshwant Mahavidyalaya, Nanded- 431602 (M.S.), India.

Sarla Kalyankar
P.G. Department of Studies in Chemistry, Organic Research Laboratory, Yeshwant Mahavidyalaya, Nanded- 431602 (M.S.), India.

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