Telmisartan (TLM) is an angiotensin receptor blocker (ARB)
that has an extensive period of working and has the lengthy half-life of any
ARB. Telmisartan works by blocking a substance in the body that causes blood
vessels to tighten. This work is intended to thrive a stability-indicating
Ultra performance liquid chromatographic method for the estimation of
Telmisatam (TLM) and Hydrochlorothiazide (HCTZ) and degradation products
pharmaceutical dosage forms. Separation was carried out on Zorbax Eclipse XDB
C-18(50 x mm, 1.7 µm) column using a gradient method. Mobile phase A is 10mM
KH2PO4 having 1% (v/v) of trimethylamine and mobile phase B is acetonitrile
used in this work. 0.5 mL/ minute is the flow rate and at 271 nm noticed
wavelength is monitored. Method development trails were carried out on six
different columns. For specificity, limit of quantification, limit of
detection, linearity, accuracy, method precision, robustness and stability this
method is validated. The correlation coefficient of the impurities is more than
0.99. The stability indicating method confirmed that there was no interference
of all impurities of TLM and HCTZ. TLM and HCTZ tablet samples stored and
long-term storage conditions. The effect of storage conditions results proved
that the method has stability indicating capability. Hence, the developed LC
method was stability indicating and well applied for drug product stability
study as well as for quality monitoring.
Author(s) Details:
Narasimha Reddy G. P,
Department of Chemistry, Sri Krihnadevaraya University Anantapur,
Anantapuramu, Andhra Pradesh, India.
Sreenivasulu Reddy T.
Department of Chemistry, Sri Krihnadevaraya University Anantapur, Anantapuramu,
Andhra Pradesh, India.
Sidda Reddy K.
Department of Chemistry, Sri Krihnadevaraya University Anantapur, Anantapuramu,
Andhra Pradesh, India.
Shashi Kumar K. N.
Department of H&S, Annamacharya Institute of Technology & Sciences,
Kadapa, 516003, Andhra Pradesh, India.
Please see the link here: https://stm.bookpi.org/ACPR-V9/article/view/14362
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