Exploring the Synthesis, Isolation, and Characterization of a Derivative of (Pyrazol-4-yl)acetic Acid within the Framework of Chemical Investigation | Chapter 6 | Current Innovations in Chemical and Materials Sciences Vol. 9

 

The present investigation is related to the construction of novel 3-(3-bromophenyl)-2-(1,3-diphenyl-1H-pyrazol-4-yl)acrylic acid by reacting methyl 1,3-diphenyl-1H-pyrazole-4-carboxylate with 3-bromophenyl aldehyde. The hydrazone prepared from acetophenone and phenyl hydrazine was subjected to the Vilsmeier-Haack reagent and after the usual workup, 4-formyl pyrazole was obtained. The 4-formylpyrazole was further converted into methyl pyrazole-4-carboxylate via various intermediates such as (1,3-diphenyl-1H-pyrazol-4-yl)methanol, 4-(chloromethyl)-1,3-diphenyl-1H-pyrazole, and 2-(1,3-diphenyl-1H-pyrazol-4-yl)acetonitrile. The methyl 1,3-diphenyl-1H-pyrazole-4-carboxylate is a key scaffold that was further used for Knoevenagel condensation with substituted aldehydes to get the (pyrazol-4-yl)acetic acid derivatives. All intermediates and the final target were characterized by their spectral data.

Author(s) Details:

Karan Singh,
Department of Chemistry, Indira Gandhi University, Meerpur, Rewari-122502, Haryana, India.

Harshita Phougat
Department of Chemistry, Indira Gandhi University, Meerpur, Rewari-122502, Haryana, India.

Please see the link here: https://stm.bookpi.org/CICMS-V9/article/view/14337