Hepatitis E virus (HEV), a member of the family Hepeviridae, is the major cause of hepatitis E infections across the globe. Though the open reading frame 4 (ORF4) indispensability in the replication of HEV has been demonstrated, its physicochemical properties remain to be explored. Therefore, a thorough investigation of the physical and chemical properties of the ORF4 proteins, obtained from various HEV isolates, was carried out to examine their peculiar characteristics. The physicochemical properties considered for the present study included a number of charged amino acid residues, instability indices, aliphatic indices and grand average of hydropathy (GRAVY) scores. The comparative analyses predicted the basic, unstable, thermostable and hydrophobic nature of the ORF4 proteins. Delineation of various physicochemical components of ORF4 will assist in revealing specific patterns of these proteins, further which will increase our knowledge of HEV biology.
Author(s) Details
Zoya Shafat
Centre for Interdisciplinary Research in Basic Sciences,
Jamia Millia Islamia, New Delhi 110025, India.
Please see the link:- https://doi.org/10.9734/bpi/mono/978-81-976932-1-2/CH2
No comments:
Post a Comment