Exploring Aegle marmelos Polysaccharide: A Natural Matrix Former for Advanced Drug Delivery Systems | Chapter 7 | Pharmaceutical Research: Recent Advances and Trends Vol. 9

Background: The objective of this study was to formulate sustained-release metoprolol succinate tablets using Aegle marmelose (Bael), a plant from the Rutaceae family, as a natural matrix-forming polymer. Excipients play a crucial role in enhancing tablet quality, and Aegle marmelose polymers, like synthetic polymers, offer promising potential as matrix formers in advanced drug delivery systems. These polysaccharide gums are abundant, biocompatible, biodegradable, and non-immunogenic. Additionally, they promote economic growth by enabling the production of cost-effective formulations with locally available components. These polymers can be modified to achieve desired properties, making them comparable to synthetic additives in drug delivery applications.

Results: The fruits of Aegle marmelose were used as a binder in the formulation of metoprolol succinate matrix tablets. A 3² factorial design (F1 to F9) was employed to develop the tablets, and batch F6 was evaluated for weight variation, hardness, friability, drug content, drug release, stability, solubility, swelling properties, and excipient compatibility.

Conclusion: Aegle marmelose polysaccharide proved to be a more suitable natural binder for the sustained-release metoprolol succinate tablets compared to synthetic alternatives, with no significant changes observed in the formulated and stabilized tablets. This study also aimed to explore the potential of natural polysaccharides as viable excipients in drug delivery systems.

 

Author (s) Details

 

Aishwarya S.Patil
Vilasrao Deshmukh Foundation Group of Institution, VDF School of Pharmacy, Latur (413531), Maharashtra, India.

 

Rushikesh A.Gurav
Department of Pharmaceutics, VDF School of Pharmacy, Latur, MH-413531, India.

 

Saber F.Shaikh
Department of Pharmaceutics, VDF School of Pharmacy, Latur, MH-413531, India.

 

Rushikesh N.Bharade
Department of Pharmaceutics, VDF School of Pharmacy, Latur, MH-413531, India.

 

Rutuja R.Kakade
Department of Pharmaceutics, VDF School of Pharmacy, Latur, MH-413531, India.

 

Adarsh B.Jadhav
Department of Pharmaceutics, VDF School of Pharmacy, Latur, MH-413531, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/prrat/v9/3008