Exploring Aegle marmelos Polysaccharide: A Natural Matrix Former for Advanced Drug Delivery Systems | Chapter 7 | Pharmaceutical Research: Recent Advances and Trends Vol. 9

Background: The objective of this study was to formulate sustained-release metoprolol succinate tablets using Aegle marmelose (Bael), a plant from the Rutaceae family, as a natural matrix-forming polymer. Excipients play a crucial role in enhancing tablet quality, and Aegle marmelose polymers, like synthetic polymers, offer promising potential as matrix formers in advanced drug delivery systems. These polysaccharide gums are abundant, biocompatible, biodegradable, and non-immunogenic. Additionally, they promote economic growth by enabling the production of cost-effective formulations with locally available components. These polymers can be modified to achieve desired properties, making them comparable to synthetic additives in drug delivery applications.

Results: The fruits of Aegle marmelose were used as a binder in the formulation of metoprolol succinate matrix tablets. A 3² factorial design (F1 to F9) was employed to develop the tablets, and batch F6 was evaluated for weight variation, hardness, friability, drug content, drug release, stability, solubility, swelling properties, and excipient compatibility.

Conclusion: Aegle marmelose polysaccharide proved to be a more suitable natural binder for the sustained-release metoprolol succinate tablets compared to synthetic alternatives, with no significant changes observed in the formulated and stabilized tablets. This study also aimed to explore the potential of natural polysaccharides as viable excipients in drug delivery systems.

 

Author (s) Details

 

Aishwarya S.Patil
Vilasrao Deshmukh Foundation Group of Institution, VDF School of Pharmacy, Latur (413531), Maharashtra, India.

 

Rushikesh A.Gurav
Department of Pharmaceutics, VDF School of Pharmacy, Latur, MH-413531, India.

 

Saber F.Shaikh
Department of Pharmaceutics, VDF School of Pharmacy, Latur, MH-413531, India.

 

Rushikesh N.Bharade
Department of Pharmaceutics, VDF School of Pharmacy, Latur, MH-413531, India.

 

Rutuja R.Kakade
Department of Pharmaceutics, VDF School of Pharmacy, Latur, MH-413531, India.

 

Adarsh B.Jadhav
Department of Pharmaceutics, VDF School of Pharmacy, Latur, MH-413531, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/prrat/v9/3008

Medicinal and Phytochemical Profiling of Aegle marmelos | Chapter 4 | Contemporary Research and Perspectives in Biological Science Vol. 8

Aegle marmelos (L) is native to the Indian subcontinent and Southeast Asia and well known for its therapeutic values such as anti-diabetic activity, hepatoprotective activities, antimicrobial activity, analgesic anti-inflammatory, antifungal activity, anticancer activity, antiulcer activity, antithyroid activity, etc. Present studies report phytochemical analysis, and antifungal antibacterial screening of acetone, ethanol and methanol leaf extract of Aegle marmelos. The plant material leaves of Aegle marmelos were collected from Cove and John Ashram, Georgetown, Guyana. Leaves are dried in the oven at 50-55 ºC for 72 h. The moisture content is calculated. The dried leaves were ground and extracted in each acetone, ethanol and methanol solvent. Extracts were collected and evaporation of solvent was done on rotavapour. The antimicrobial and antifungal activity of leaf extract was examined by well diffusion, poison plate, paper disc plate and streak plate methods. Three micro-organisms (Escherichia coli, Staphylococcus aureus and Candidus albicans) were used for the study as test organisms. In Aegle marmelos leaf extract studies, maximum and minimum antimicrobial potential was observed for methanol and acetone solvents, respectively. The antimicrobial potential of leave extract was also found to be maximum and minimum in Candida albicans and Escherichia coli, respectively in most assay studies. The maximum inhibitory zone for methanolic leaves extract of Aegle marmelos were observed to be (125 µL: 0.47mm), (125 µL: 0.51 mm), (125 µL: 0. 47mm) and (125 µL: 0.37 mm) by well diffusion, poison plate, paper disc plate and streak plate methods respectively. The phyto constituents, tannins, flavonoids, alkaloids, terpenoids, phenol, steroids and Phyto steroids were found to be present in the methanol leave extract of Aegle marmelos. It is concluded that Aegle marmelos extracts can be used for the treatment of tuberculosis, urinary disease, diabetes, digestive disorder, epilepsy, ulcers etc.

 

Author (s) Details

 

Brij Bhushan Tewari
Department of Chemistry, Faculty of Natural Sciences, University of Guyana, P.O. Box: 101110, Georgetown, Guyana

 

Subramanian Gomatinayagam
University of Guyana, Berbice Campus, John Science Center, Guyana.

 

Ashish Kumar Tiwari
Advanced Center for Material Science, Indian Institute of Technology Kanpur, Kanpur-206016, Uttar Pradesh, India

 

Please see the book here:- https://doi.org/10.9734/bpi/crpbs/v8/3394

Exploring Aegle marmelos Polysaccharide: A Natural Matrix Former for Advanced Drug Delivery Systems | Chapter 7 | Pharmaceutical Research: Recent Advances and Trends Vol. 9

 

Background: The objective of this study was to formulate sustained-release metoprolol succinate tablets using Aegle marmelose (Bael), a plant from the Rutaceae family, as a natural matrix-forming polymer. Excipients play a crucial role in enhancing tablet quality, and Aegle marmelose polymers, like synthetic polymers, offer promising potential as matrix formers in advanced drug delivery systems. These polysaccharide gums are abundant, biocompatible, biodegradable, and non-immunogenic. Additionally, they promote economic growth by enabling the production of cost-effective formulations with locally available components. These polymers can be modified to achieve desired properties, making them comparable to synthetic additives in drug delivery applications.

Results: The fruits of Aegle marmelose were used as a binder in the formulation of metoprolol succinate matrix tablets. A 3² factorial design (F1 to F9) was employed to develop the tablets, and batch F6 was evaluated for weight variation, hardness, friability, drug content, drug release, stability, solubility, swelling properties, and excipient compatibility.

Conclusion: Aegle marmelose polysaccharide proved to be a more suitable natural binder for the sustained-release metoprolol succinate tablets compared to synthetic alternatives, with no significant changes observed in the formulated and stabilized tablets. This study also aimed to explore the potential of natural polysaccharides as viable excipients in drug delivery systems.

 

Author(s)details:-

 

Aishwarya S.Patil
Vilasrao Deshmukh Foundation Group of Institution, VDF School of Pharmacy, Latur (413531), Maharashtra, India.

 

Rushikesh A.Gurav
Department of Pharmaceutics, VDF School of Pharmacy, Latur, MH-413531, India.

 

Saber F.Shaikh
Department of Pharmaceutics, VDF School of Pharmacy, Latur, MH-413531, India.

 

Rushikesh N.Bharade
Department of Pharmaceutics, VDF School of Pharmacy, Latur, MH-413531, India.

 

Rutuja R.Kakade
Department of Pharmaceutics, VDF School of Pharmacy, Latur, MH-413531, India.

 

Adarsh B.Jadhav
Department of Pharmaceutics, VDF School of Pharmacy, Latur, MH-413531, India.

 

Please See the book here :- https://doi.org/10.9734/bpi/prrat/v9/3008

Updating the Antibacterial & Antiulcer Activity of Aegle Marmelos Linn | Chapter 10 | Technological Innovation in Pharmaceutical Research Vol. 11

Antimicrobial medications are antibiotics that are used to treat infections caused by bacteria. Pathogenic microorganisms are microorganisms that cause disease. Antimicrobial drugs, such as antibiotics, antiviral, antifungal, and antiparasitic medicines, are used to treat diseases. These microorganisms not only cause sickness in people, but also in animals and plants. Antimicrobial resistance (AMR) occurs when disease-causing microorganisms develop resistance to antibiotics, rendering the drugs ineffective. This makes common infections more difficult to treat, increasing the risk of serious illness, disease spread, and death. According to a World Health Organization (WHO) research, AMR instances are on the rise, posing a challenge for effective treatment and prevention of illnesses caused by microorganisms such as bacteria, viruses, fungi, and parasites. AMR renders treatments ineffective, allowing illnesses to persist in the body and increase the risk of spreading to others. The World Health Organization advocates reducing the use of synthetic antibiotics and increasing the use of herbal antimicrobial medications. AMR can be managed or eradicated if only these methods are used. Herbal medicines are thought to be both therapeutically and side-effect-free. Aegle Marmelos Linn. (Bael in Hindi) is a very potent herbal medication that has been covered in this chapter. Aegle marmelos Linn. is beneficial for a variety of diseases. It has anticonvulsant, antioxidant, antihyperglycemic, anxiolytic, antidepressant, antihistaminic, antimicrobial, hepatoprotective, analgesic, immunological modulatory, cardio protective, and antithyroid activity, according to scientific investigations. It is used to treat peptic ulcer patients because of its antibacterial and antiulcer properties. Helicobacter pylori is the bacteria that causes a peptic ulcer. The effect of Aegle Marmelos on germs, especially Helicobacter pylori, is discussed in this chapter.

Author (S) Details

Tapan Kumar Mahato
Department of Pharmaceutical Pharmacology, Post Graduate Studies, Bhupal Nobles University, Udaipur, Rajasthan, India.

Komal Sharma
Department of Pharmaceutical Pharmacology, Post Graduate Studies, Bhupal Nobles University, Udaipur, Rajasthan, India.

View Book :- https://stm.bookpi.org/TIPR-V11/article/view/3132

Pharmacognostic Evaluation of Aegle marmelos (L.) Correa. Leaves | Chapter 5 | Technological Innovation in Pharmaceutical Research Vol. 6

 Aegle marmelos (L.) Correa, sometimes known as "Bael," is an endangered medicinal tree native to India. The leaves have a wide range of therapeutic characteristics that are employed in traditional medicine. Pharmacognostic investigations can be used to verify the authenticity of a medicinal plant sample. Aegle marmelos leaves had a stomatal index of 70.83 percent with paracytic stomata, according to pharmacognostic analysis. Secondary growth in the vascular bundle was visible in a transverse section of mature leaves. Patches of sclerenchymatous fibres were used to symbolise the pericycle. Underneath the epidermis, large resin channels could be seen. Phenols, terpenoids, flavonoids, gums, resins, steroids, saponins, and glycosides were found in the aqueous extract after phytochemical investigation. When treated with sodium hydroxide, the fluorescence analysis revealed flourescent green emission, indicating the presence of flavonoid. Trichomes were not found in the powder, although resin globules and fibres were visible.

Author (s) Details

S. Kanimozhi
Department of Plant Biology and Plant Biotechnology, Ethiraj College for Women, Ethiraj Salai, Egmore-600008, Chennai, India.

Dr. R. Anitha
Bharathi Women’s College, Broadway-600108, Chennai, India.

View Book :- https://stm.bookpi.org/TIPR-V6/article/view/1705