The reticular nucleus of the thalamus (TRN) has attracted
special attention among diencephalic structures, which are specially related to
the genesis of the electrical activity of brain. Brain stem formations also
appear to be able to change the activity of other parts of the brain. The aim
of this investigation was to study the mechanisms of the relationship between
TRN, mesencephalic reticular formation (MRF) and nucleus of the solitary tract
(NTS). It has been shown, for the first time, that: firstly, TRN and MRF are
functionally interrelated and affect each other reciprocally - activation of TRN
mainly inhibits the activity of MRF neurons and vice versa; secondly,
stimulation of NTS led to the activation of TRN neurons. Moreover, when
recording the activity of TRN and MRF neurons with two microelectrodes, it was
shown that, upon NTS stimulation, deep inhibition of MRF neurons occurred in
parallel with the activation of TRN neurons. Based on our results, it is
possible to make some adjustments to the scheme of the relationship between the
synchronizing and desynchronizing structures when changing the functional state
of the brain and the place of TRN in this activity. Taken together, these
findings indicate that the brainstem exerts substantial control over the
activity of TRN neurons, possibly to globally modulate the level of arousal for
preparing for consciousness.
Author(s) Details:
Z. I. Nanobashvili,
Laboratory of Neurophysiology, I. Beritashvili Center of
Experimental Biomedicine, Tbilisi, Georgia.
I. G. Bilanishvili,
Laboratory
of Neurophysiology, I. Beritashvili Center of Experimental Biomedicine,
Tbilisi, Georgia.
B. B. Buachidze,
Ilia State University, Tbilisi, Georgia.
M. D. Barbakadze,
Laboratory of Neurophysiology, I. Beritashvili Center of
Experimental Biomedicine, Tbilisi, Georgia and Teaching University “GEOMEDI”,
Tbilisi, Georgia.
N. A. Khizanishvili,
Laboratory of Neurophysiology, I. Beritashvili Center of
Experimental Biomedicine, Tbilisi, Georgia.
Please see the link here: https://stm.bookpi.org/NVMMS-V7/article/view/14230
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