Background: Pancreatic squamous cell carcinoma is an
uncommon condition, and little is known about its pathogenesis. The only
possible curable procedure is surgical resection. Palliative care is typically
administered for recurrent local-regionally located pancreatic carcinomas, as
they are typically incurable.
Aim: The purpose of the study is to present the treatment
strategy of a recurrent squamous cell pancreatic carcinoma with peritoneal
carcinomatosis.
Case Report: A 49-year-old man with local-regional recurrent
squamous cell pancreatic carcinoma underwent complete (CC-0) cytoreductive
surgery (CRS) and hyperthermic intraoperative intraperitoneal chemotherapy
(HIPEC). In a 6-month time he underwent secondary CRS+HIPEC for regional
recurrence.
Despite treatment with adjuvant systemic chemotherapy the
patient died 12 months after the initial CRS with osseous metastases. The
biologic behavior and the clinical presentation do not differ from ductal
adenocarcinoma of the pancreas, although upper gastrointestinal tract bleeding
secondary to gastric invasion appears to be more frequent in squamous cell
pancreatic carcinomas.
Conclusions: A reliable prognosis for recurrent squamous
cell pancreatic carcinoma is difficult despite complete cytoreduction in combination
with HIPEC and systemic chemotherapy. The patient presented recurrence despite
aggressive treatment shortly after surgery. Although complete cytoreduction was
possible very shortly the patient presented distant metastatic disease and
died.
Author(s) Details:
A. Tentes,
Euromedica Kyanous Stavros, Thessaloniki, Greece.
A.
Fotiadou,
Laboratory
of Diagnostic Histopathology, Greece.
D. Kyziridis,
Euromedica Kyanous Stavros, Thessaloniki, Greece.
Ch. Hristakis,
Euromedica Kyanous Stavros, Thessaloniki, Greece.
A. Kalakonas,
Euromedica
Kyanous Stavros, Thessaloniki, Greece.
A.
Iliadis,
Laboratory
of Diagnostic Histopathology, Greece.
Please see the link here: https://stm.bookpi.org/NVMMS-V7/article/view/14224
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