Background: The prevalence of diabetes mellitus is
increasing worldwide and recent estimates indicate that one out of three people
will develop diabetes during their lifetime. Diabetes is a growing public
health burden across the world, particularly in developing countries.
Homeostasis of trace elements such as magnesium has been found to play an
important role in the pathogenesis of diabetes and diabetic complications.
Studies have found out an association between serum magnesium and incident
diabetes; where diabetes may induce urinary magnesium loss. However, in
pre-diabetes, serum glucose levels are below the threshold for urinary
magnesium wasting and hence unlikely to influence serum magnesium levels. This
study was done to assess their serum magnesium levels and find their
correlation.
Methods: This cross-sectional study was done among 120
pre-diabetic subjects. Pre-diabetes was diagnosed as per ADA guidelines and
body mass index was calculated according to Asian guidelines of BMI. Serum
magnesium levels were done for all of them and statistically analysed to
correlate the serum magnesium with body mass. All the statistical data were
analysed using the Statistical Package for Social Sciences.
Results: The present study observed that 69 out of 120 pre-diabetics,
57.5% have low magnesium levels. This study showed that 57.5% of pre-diabetics
have normal body mass index, out of which more than half of them have normal
serum magnesium. But out of 12 obese pre-diabetics, 11 had low serum magnesium
91.6%. (P value 0.026 which is statistically significant).
Conclusions: This study observed that serum magnesium levels
are low in Pre-diabetics. Significant hypomagnesemia has been seen in
pre-diabetics with high BMI compared to those with normal BMI. Further studies
will be needed to elaborate on this association, monitoring the diets and
physical activity in a larger population.
Author(s) Details:
Ajeesh Koshy,
Department of Medicine, Pushpagiri Medical College, Thiruvalla,
Kerala, India.
Roshan
M.,
Department
of Medicine, Father Muller Medical College, Mangalore, Karnataka, India.
Please see the link here: https://stm.bookpi.org/ANUMS-V8/article/view/13554
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