Abnormal DNA amounts are mostly caused by changes in the
number of chromosomes and chromosomal deletions. The aim of this study is to further
investigate if DNA aneuploidy can serve as an early marker of malignant
transformation of colorectal adenomatous polyps. The study was performed on 50 colorectal
polyps obtained through endoscopic polypectomy from 46 patients, aged 30 to 80,
with a mean age of 60. One interesting observation in our study refers to the
DNA index in polyps with focal carcinomatous lesions, in which the
carcinomatous areas have similar DNA indexes to those from the strictly
adenomatous regions of the polyp. The significant association between DNA
aneuploidy and the size of the polyps is vital, as size is considered one of
the most important predictors of carcinomatous transformation in an adenoma,
followed in predictive ability by histopathological type and degree of dysplasia.
Author(s) Details:
Stoian Marilena,
Department of Internal Medicine, Carol Davila University of Medicine
and Pharmacy, Bucharest, Romania and Internal Medicine Department, “Dr. Ion
Cantacuzino” Clinical Hospital, Bucharest, Romania.
Please see the link here: https://stm.bookpi.org/ACPR-V7/article/view/13539
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