This member evaluate the analgesic venture of Levofloxacin in male albino rats. Levofloxacin (LFX) is a general fluoroquinolone antibiotic used in the situation of infections in the way that pneumonia, chronic bronchitis, and sinusitis. It is a chosen drug accompanying better efficacy in the treatment of typhoid turmoil especially when distinguished with other appendages of the same classification such as ciprofloxacin.The animal study a cross sectional, practical study, conducted in Institute of Pharmacology, Madurai Medical institution of higher education, Madurai, India. Thirty adult albino rats deliberation 150-250 gm were obtained from central animal family. The animals were detached into five groups of six animals each. Using Current's hot plate and tail flick methods, the analgesic impact of levofloxacin was determined and contrasted with that of anesthetic, a common painkiller. Statistical analysis of distinctness between groups were carried out utilizing one-way reasoning of variance using SPSS form 20.Findings from our study displayed that Levofloxacin prolonged the reaction occasion both in tail-flick and in the portable stove method. Levofloxacin at 40 mg/kg application showed a higher antinociceptive venture compared to anesthetic at 90 min and 120 min in rats that indicates that it has a determined analgesic action that maybe explained due to allure long duration of operation. Comparing levofloxacin to the control and standard groups, it has demonstrated bright analgesic belongings. It might be a promising novel fragment to find adjuvant analgesics. Since the dossier from animals cannot be shortly applied to humans, more research is necessary to validate these verdicts in humans.
Author(s) Details:
Prasanna Kumari S.,
Department
of Pharmacology, GMC-ESI Hospital, Coimbatore, Tamil Nadu, India.
Latha
K.,
Department
of Pharmacology, GMC-ESI Hospital, Coimbatore, Tamil Nadu, India.
Meeradevi A.,
Department of Pharmacology, GMC-ESI Hospital, Coimbatore, Tamil
Nadu, India.
Please see the link here: https://stm.bookpi.org/ACPR-V3/article/view/12768
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