Proponents Implemented for Quality Standardization and Toxicity Evaluation of Classical Ayurvedic Formulation: Dhatupaushtik Churna| Chapter 11 | Current Overview on Pharmaceutical Science Vol. 1

 Dhatupaushtik Churna is a polyherbal grated formulation that contains equal amounts of Gokhru (Tribulus terrestris L.; Family: Zygophyllaceae), Ashwagandha (Withania somnifera L.; offspring: Solanaceae), and Safed musli (Chlorophytum borivilianum L.; Family: Asparagaceae) and is used to treat a myriad of ailments, containing premature ejaculation, proneness, rejuvenation of the male reproductive structure, and anti-aging. The fundamental goal of this case is to document Dhatupaushtik Churna's distinctive traits in order to legitimise its labeling, quality, and purity. The many specifications investigated included organoleptic characteristics, physicochemical limits, physical characteristics of Churna, preliminary phytochemical, sounds that are pleasant, and microbial analysis, metabolomic tracking accompanying gas chromatography/bulk spectrometry, and high-performance thin coating chromatography assessment. The parameters settled have been shown expected informative finishes for assisting regulatory experts, scientific organisations, and manufacturers in developing extreme-efficacy standard formulations, and they can be secondhand as reference principles in a pharmaceutical startup's quality control/control of product quality laboratory. As a consequence of this inquiry, each and every ingredient in Dhatupaushtik Churna maybe identified. The characterisation limits documented in this essay might be used as a standard criterion for Dhatupaushtik Churna quality control analysis. To support batch-to-parcel consistency, the criteria likely in this study might be utilised to develop a monograph on quality flags for Dhatupaushtik Churna.Furthermore, the study evaluated the severe and subacute oral toxicity of Dhatupaushtik Churna aqueous extract in Swiss light mice and Wistar albino rats. Acute toxicity evaluation was studied utilizing male Swiss albino mice evaluating 20-25 gm and the subacute toxicity testing was using male Wistar light rats weighing 150-200 gm. The acute toxicity study was completed activity according to OECD (Organisation for Economic Co-operation and Development) directions 423, at the dose of 2000 mg/kg, p.o., with no fatalities. In a subacute toxicity search, the extract-treated rats (200 and 400 mg/kg, p.o.) showed no important differences compared to the control group. Haematological and biochemical flags were constant, inasmuch as the weights of the liver, kidney, pancreas, and organs did not alter. The results displayed that Dhatupaushtik Churna had no appreciable impact on the limits assessed at the doses secondhand in the study. However, further study is required to examine and confirm its security.

Author(s) Details:

Kausik Bhar,
GITAM School of Pharmacy, GITAM (Deemed to be University), Visakhapatnam-530045, A.P., India.

Sumanta Mondal,
GITAM School of Pharmacy, GITAM (Deemed to be University), Visakhapatnam-530045, A.P., India.

Please see the link here: https://stm.bookpi.org/COPS-V1/article/view/8970