Friday, 15 October 2021

Assessing the Importance of Non-Necrotising Granulomatosis | Chapter 10 | New Frontiers in Medicine and Medical Research Vol. 17

 In clinical practise, the diagnosis of non-necrotising granulomatosis (NNG) is fairly common. However, there are few studies within the spectrum of illnesses that produce NNG, hence little information is known except for sarcoidosis. The goal is to find out how common sarcoidosis, autoimmune illnesses, and other diseases are in NNG.

Methods: From January 1, 2010 to December 31, 2014, we gathered all pathology reports in the Clinical University Hospital of Santiago de Compostela, Spain, with a diagnosis of non-necrotising granulomatosis.

The researchers looked at 290 tissue samples from 207 patients. 50.7 percent of the patients were female, with a mean age of 51.2 years. Skin 32.9 percent, lymph nodes 26.6 percent, transbronchial biopsy 14.5 percent, lung 5.8 percent, and others 20.2 percent were the sources of the samples. Sarcoidosis accounted for 59.9% of diagnoses, followed by infectious diseases (7.7%), which included tuberculosis (4.0%) and non-tuberculous mycobacterial infection (1.4%), foreign body granulomatosis (6.3%), neoplasms (5.1%), autoimmune disease (3.1%), and others (4.0%). In 5.9% of cases, a diagnosis could not be made.

Conclusion: The incidence of sarcoidosis in NNG is over 50%, while the prevalence of autoimmune diseases is much lower (3.1%), with Wegener granulomatosis being the most frequent. Infectious disease, particularly tuberculosis, was the most common alternative diagnosis. However, the likelihood of malignancy must be considered. In the vast majority of situations, a precise diagnosis is possible.

Author(S) Details

Vanesa Alende-Castro
Department of Internal Medicine, Salnés Hospital, Galician Healthcare Service (SERGAS), Villagarcia, Spain.

View Book:- https://stm.bookpi.org/NFMMR-V17/article/view/4209

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