It has been assumed that the incidence of renal failure is a common complication in children with nephrotic syndrome associated with minimal change disease. It has however been recorded relatively less frequently in adults than in infants. In nephrotic syndrome, acute kidney injury (AKI) has been identified in literature and has been related to older age, systolic hypertension, vascular disease, and increasing severity of nephrotic syndrome. A matter of question has been the underlying pathophysiology responsible for reducing glomerular filtration rate (GFR). We present a case of an elderly patient with worsening renal failure and analyse the available literature on this AKI entity in adult nephrotic syndrome with limited improvement. The long-term outlook is difficult to define for adult patients, especially elderly patients with pre-existing medical conditions with AKI, though generally nice, and more long-term follow-up studies explicitly addressing this issue are required. It is also not clear that the various treatment regimens at this stage correlate with improved renal function recovery and are still to be identified.
Author(s) Details
Department of Nephrology, K. S. Hegde Medical Academy, Medical Sciences Complex, Derlakatte Mangalore 575018, Karnataka, India.
M. Pradeep Shenoy
Department of Nephrology, K. S. Hegde Medical Academy, Medical Sciences Complex, Derlakatte Mangalore 575018, Karnataka, India.
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