Impact of MGNREGA on Tribal Livelihoods of Santhal Households in Pakur District of Jharkhand, India | Chapter 2 | Economics, Business and Management: Recent Advances Vol. 1

 

The Mahatma Gandhi National Rural Employment Guarantee Act (MGNREGA) is a pivotal welfare program in India, designed to ensure 100 days of guaranteed wage employment for rural households. The objectives of the act are to provide safety nets for vulnerable groups, provide an engine for the agricultural sustainable development, empower the rural poor and promote new ways of doing businesses by providing work for unskilled workers at the wage rate specified by the Central Government. For tribal communities like the Santhals of Pakur district (Jharkhand), MGNREGA has the potential to function as both a safety net and a catalyst for livelihood security. The study aims to find out the extent of participation of MGNREGA among Santhal households in Pakur. This study assesses the influence of MGNREGA on income, migration, and household consumption within Santhal households in Pakur district. Primary data were gathered utilising a stratified random sampling method to guarantee representation among the socio-economic strata of Santhal households. The survey encompassed 150 households, with 25 households chosen from each of six blocks—Pakuria, Maheshpur, Pakur, Amrapara, Littipara, and Hiranpur—establishing a solid foundation for evaluating the program's impact on the community. The data were examined through descriptive statistics and the Wilcoxon Signed-Rank Test methodologies after testing the data for normality. The results indicate a statistically significant upward shift in income categories and a reduction in reported seasonal migration following participation in MGNREGA. MGNREGA participation contributed to improved economic well-being, as evidenced by consumption trends, with most households reporting heightened consumption, signifying better access to food and essential goods. The research concludes that MGNREGA has favourably impacted the socio-economic status of Santhal households. The research highlights the necessity for MGNREGA to focus on the development of productive community assets, including irrigation facilities, land development structures, and water harvesting systems, to improve the livelihood resilience of tribal households. It advocates for enhancing execution to achieve more comprehensive livelihood advancements.

 

 

Author(s) Details

Amar Kumar Chaudhary
Department of Commerce and Business Management, Ranchi University, India.

 

Shashi Shekhar Murmu
Department of Commerce and Business Management, Ranchi University, India.

 

Please see the book here :- https://doi.org/10.9734/bpi/ebmra/v1/6964

Determinants of Agriculture as a Career Path among College Students in Mezam Division of Northwest Cameroon | Chapter 8 | Agricultural Sciences: Techniques and Innovations Vol. 3

 

In Sub-Saharan Africa (SSA), agriculture continues to play a fundamental role in the economic portfolio of rural households. However, rapid urban growth—particularly in Africa—is increasingly fueled by two key factors: internal migration from rural to urban areas, and immigration from other countries and regions. Generally, youths in rural Africa have little aspiration for careers in the agricultural sector and instead migrate to urban areas to seek employment and better living conditions. In Cameroon, the majority of migrants are youths aged 18 to 35, who often face significant challenges related to unemployment and underemployment upon arriving in urban areas. The government is turning to agriculture as a source of employment for youth; however, there is scant literature on the determinants of the attraction of youths, especially college students, to the sector. This exploratory study sought to identify these determinants and to investigate strategies for making agriculture appealing to students for future career development. A cross-sectional study was conducted from March to June 2023 across selected secondary and high schools. In both secondary and high schools, a semi-structured questionnaire comprising twelve open-ended and three closed-ended questions was first piloted. Based on the pilot, an average of eight students per institution were selected for individual interviews, and eight others participated in focus group discussions. Secondary and high school teachers, selected using the convenience sampling approach, were engaged in focus group discussions. Thematic analysis was conducted using NVivo software. The overarching factors attracting college students to agriculture in the study area include the availability of arable land and easy access to it, access to start-up financing, the introduction of adapted mechanization and relevant information and communication technologies, increased productivity leading to higher returns on investment in agriculture, education and training, and positive messaging about agriculture targeting youth. The study recommends profound land tenure reforms, the provision of adapted financial services, the establishment of farm mechanization pools, the inclusion of agriculture in college curricula, and positive communication strategies to rebrand agriculture. Further research should be carried out in other regions of the country to confirm the findings of this study or to identify other contributory factors of youth attraction to agriculture, which may be specific to the different agro-ecological zones of the country.

Author(s) Details

Aseh Emmanuel Vitung
Department of Business Studies, Graduate School, ICT University, Yaounde, Cameroon.

 

Please see the book here:- https://doi.org/10.9734/bpi/asti/v3/5827

 

Examining the Causes and Economic Impact of Rural-Urban Migration | Book Publisher International

This research paper aims to study migration from rural to urban areas with the main concern that by the year 2050, it’s expected that 60% of the total world population will reside in urban areas. This is by all means a major transition from the 1950s when only 30% of the population resided in urban areas. The major concern here is whether developing economies will be prepared enough to cope with the socio-economic and political implications of this transition.

 

This study aims at adding value to already existing literature on migration patterns by looking at other possible factors that may cause rural-urban migration like social ties and relationships among other traditional factors like age, sex, marital status, income expectations and family size.

 

This research critically examines the effects of education on migration decisions by analyzing data on the level of education attained by the time a migrant makes a decision to migrate. The study found that most of the migrants to the urban areas have attained little or no education at all and the majority only have a primary level of education. The study also examines the socio-economic and environmental concepts associated with rural-urban migration such as the mushrooming of slum dwellings, urban unemployment, crime, environmental degradation and other social vices like drug peddling hawking and prostitution.

 

This study aims at suggesting policy recommendations based on the findings which can be of use to policymakers and the Government as they try to tackle this problem. Of great importance as found out in the study is the need to develop infrastructure in the rural areas, and create income-generating activities and employment opportunities in these areas in order to minimize urban migration. This should be followed by a Government-regulated and planned expansion of the urban informal sector to control the emergence of slum dwellings and unplanned economic activities. Finally, this study proposes areas that require further research such as the effect of technology, digitization of the economy effects of internet connectivity and mobile banking in influencing future migration patterns from rural to urban areas.

 

Author (s) Details

 

Mr. Simon Wangombe Ngai
University of Nairobi, Kenya.

 

Prof. L. P Mureithi
University of Nairobi, Kenya.

 

Dr. S. M Nyandemo
University of Nairobi, Kenya.

 

Please see the book here:- https://doi.org/10.9734/bpi/mono/978-93-48859-09-9

 

Environmental Change, Riverbank Erosion and Human Migration: A Review | Chapter 7 | Geography, Earth Science and Environment: Research Highlights Vol. 3

This paper is an attempt to investigate the relationship between environmental factors and human migration. In this regard, various studies available on migration are reviewed and compiled their findings. The literature was reviewed and analysed using descriptive technique which mostly followed in qualitative research. On the basis of a review of the literature, it has been observed that riverbank erosion is a burning issue in Bangladesh as well as in India, which is caused by floods. Due to riverbank erosion, a huge area eroded every year and it displaced a lot of inhabitants from the riverbank areas. The individuals lose their entire properties, leaving them with limited employment opportunities and reduced financial resources, which heightens the risk of food insecurity. However, the impact of riverbank erosion is not similar in all the areas. Somewhere, the impact is low and somewhere the impact is severe which permanently displaces the inhabitants. Hence, the displaced people are compelled to migrate in search of livelihood. Finally, the paper suggests further in-depth study to analyse the problem and control the riverbank erosion and migration.

 

Author (s) Details

Dimpal Dekaraja
Department of Economics, Nowgong College (Autonomous), India.

Ratul Mahanta
Department of Economics, Gauhati University, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/geserh/v3/3711

Determination of Socio-Economic Characteristics of Non-Family-Reason Internal Migration in Nepal | Chapter 5 | Recent Research Advances in Arts and Social Studies Vol. 8

This study has used the socio-economic, demographic, and geographic variables from the national household survey data. The volume of an internal migration is affected by the gaps of pull and push factors between the places of origin and destination. However, the proportion of internal migration due to the family reasons could be large, which is less affected by pull and push factors. This paper studies the non-family-reason internal migration (NFIM) and shows that the non-familyreason internal migration population has different characteristics from the other population and internal migrants. The NFIM and internal migration regression coefficients had the same sign for hill/terai geographical belts, age-group, nonpoor, farm household, and ethnicity. This paper studied the NFIM population’s characteristics using the second Nepal Living Standards Survey 2003/04 data. It is possible that there are similar characteristics of the NFIM population in other geographical areas.

Author(s) Details:

Binod Manandhar,
Department of Mathematical Sciences, Clark Atlanta University, Atlanta, GA, USA.

Please see the link here: https://stm.bookpi.org/RRAASS-V8/article/view/14198

Agricultural Labour Consumption of Goods in the Market in Karnataka: An Empirical Study | Chapter 7 | Contemporary Research in Business, Management and Economics Vol. 4

 Agricultural labour is one of the primary factors of production. A large proportion of rural youth of the country is way out of agriculture. This is mainly because of rising disenchantment with the profession and better opportunities in other sectors like, manufacturing and service sectors and pulls them out of agriculture. The study was taken up in Mandya district (irrigated situation) and Bijapur district (rainfed situation) of Karnataka. From each taluk, 20 farmers were also selected randomly who were practicing farming. The total sample for the study comprised of 60 agricultural labour households and 40 farmers. The extent of dependence of households on food for consumption was calculated for the commodities which are produced on the farm like rice, ragi, field bean, red gram, vegetables, milk, egg, sugar, edible oil etc., Simple statistical tools like indices, averages, ratios and percentages were computed to interpret results properly. The results revealed that, average consumption of pulses, vegetables, fruits, milk, edible oil, sugar and egg that are rich in minerals and vitamins was compara tively higher in migration labour households compared to non-migration labour households. The total per household expenditure on food items was higher (Rs. 3883) in migration labour households in rainfed situation. The dependence of households on market for cereals and millets consumption was low in non-migration households in irrigated situation (80.52%) and highest in migration labour households in rainfed situation (88.53%). On an average, 36 per cent of cereals consumption was from public distr ibution system (PDS). PDS played an important role in food security of labour households by way of providing food grains at cheaper prices. The extent of market dependence for pulses was relatively lower in rainfed situation compared to irrigated situation. Overall market dependency of labour households for fru its and vegetables was 83 per cent in rainfed and 81 per cent in irrigated situation. The extent of market dependence for milk was low (37.98%) in non-migration labour households of irrigated situation and more in migration labour households of irrigated situation (88.89%). The extent of market dependence for egg and meat was highest in migration labour households compared to non-migration labour households.

Author(s) Details:

Venu B. N.,
Department of Agricultural Economics, College of Agricultural Sciences and Applied Research, Bharatiya Engineering Science & Technology Innovation University, India.

Suresh Babu,
College of Agricultural Sciences and Applied Research, Bharatiya Engineering Science & Technology Innovation University, India.

Ramgopal Mopuri,
College of Agricultural Sciences and Applied Research, Bharatiya Engineering Science & Technology Innovation University, India.

Please see the link here: https://stm.bookpi.org/CRBME-V4/article/view/14126

A Brief Overview on Memory Management and Reuse Mechanism for Virtual Machine in Cloud Computing to Minimize Energy Consumption | Chapter 8 | Research and Applications Towards Mathematics and Computer Science Vol. 8

In this paper, a propose technique that reduces the size of memory image stored on source host before migration. Cloud computing is an emerging computing technology for large data centers that maintains computational resources through the internet, rather than on local computers. The ultimate goal of efficient resource utilization in cloud computing is to maximize the profit for cloud providers and to minimize the cost for cloud consumers. Virtual Machine (VM) migration provides the capability to balance the load, system maintenance and fault tolerance, etc. However, existing migration techniques, used to migrate virtual machines keeping memory images of VMs in host and skipping transfer of unchanged memory pages to reduce the amount of transfer data during migration, if number of migrations increases, number of memory images stored on host are also increased, this causes memory starvation. When a VM migrates to other host, memory images of VM is kept in the source host after removing unwanted data according to the Probability factor. When the VM migrates back to the original host later, the kept memory image will be “reused”, i.e. data which are identical to the kept data will not be transferred and comparative to existing system the size of memory image is small. To validate this approach, evaluate the results using different threshold levels and probability factor of change in data. Proposed system required less memory to store the memory image and allow more VMs to be hosted. Specifically, proposed work is used to improve resource efficiency throughout by reducing the size of memory image that is stored on source host. The current work focuses on efficient memory management for source host and will reduce the memory requirement while migration. The main idea behind this concept is, whenever a VM is ready for migration from one host to another, its current state is stored on source host for future use to reduce the data transfer when it come back from the destination host after processing.

Author(s) Details:

Sandeep Kaur,
Department of Computer Science and Engineering, Punjab Institute of Technology (PTU Main Campus), PTU University, Punjab, India.

Please see the link here: https://stm.bookpi.org/RATMCS-V8/article/view/13121

Taxonomy of Internet Protocol Addressing Standards for Next Generation Internet Services | Chapter 1 | Contemporary Perspective on Science, Technology and Research Vol. 3

 This phase examines the issue of astronomically growing demand for Internet Methods participating in the public network, that has resulted in the depletion of assigned Internet Contract version 4.0 (IPV4) addresses. Each version of the cyberspace protocol has analogous characteristics and abilities. It widely studies the categories of IP address standards and physiognomy. Four Regional Computer network Registries (RIRs), namely ARNIC, RIPE, LACNIC, and ARPIN, have previously exhausted their given IPV4 addresses, while the having five of something, AFRICNIC (Africa's RIR), is pronounced to be depleted. We further investigated surplus of IPV4, the characteristics of IPV6, and several manners of operation for the IPV6 standard. The current global community is approximately 7 billion population, with a projected increase to 9 billion by 2050, and IPV6 can surely support 2128=3.4028 x 1038 devices. This study also plans a transition from current Computer network Protocol version 4.0 (IPV4) addresses to new Computer network Protocol adaptation 6.0 (IPV6) addresses. This research has revealed that installing IPV6 is simply one feasible planning for sustaining all-encompassing Internet services.

Author(s) Details:

Michael F. Adaramola,
Electrical and Electronics Engineering Department, Lagos State University of Science and Technology, Ikorodu, Lagos State, P.M.B. 21606, Ikeja, Lagos, Nigeria.

Oluwagbemiga O. Shoewu,
Electronics and Computer Engineering Department, Lagos State University, Epe Campus, Lagos State, Nigeria.

Ayoade B. Ogundare,
Electrical and Electronics Engineering Department, Lagos State University of Science and Technology, Ikorodu, Lagos State, P.M.B. 21606, Ikeja, Lagos, Nigeria.

Emmanuel B. Balogun,
Faculty of Education, Science Technology and Mathematics, University of Canberra, Australia.

Please see the link here: https://stm.bookpi.org/CPSTR-V3/article/view/12913

Determination of Antimetastatic and Antitumor Activities of Orally Administered NAX014 Compound in a Murine Model of HER2-Positive Breast Cancer| Chapter 8 | Perspective of Recent Advances in Medical Research Vol. 2

 In this study, we wanted to determine in what way or manner intragastric (IG) administration of the NAX014 compound at a dose of 20 mg/kg would influence the safety, antitumor, and antimetastatic actions as measured for one kinetics of the development of impulsive lung metastases and mammary tumours in HER-2/neu transgenic rodent. It has been demonstrated that the normal isoquinoline alkaloid Berberine (BBR) has a number of healing properties, containing anticancer activity. It has been planned and synthesised to create miscellaneous BBR derivatives so that create new substances accompanying improved anticancer productiveness. We previously accompanied that intraperitoneal (IP) administration of the BBR-derived NAX014 compound was smart to counteract HER-2 overexpressing mammary tumors beginning and progression in transgenic mice. However, the IP presidency was found to encourage organ toxicity at doses above 2.5 mg/Kg. In this study, we evaluated the effect of intragastric (IG) administration of 20 mg/kg of NAX014 on two together safety and anticancer productiveness in HER-2/neu transgenic mice. Furthermore, malignancy cell dissemination and exodus, tumor container senescence and immunological changes were checked. The present study showed that IG NAX014 administration (i) delays the incident of spontaneous mammary tumors in HER-2/neu transgenic rodent without negative effects on strength and survival; (ii) restricts breast malignancy cell migration and often major in vitro and in vivo; (iii) induces artificial and in vivo tumor containers senescence; and (iv) decreases TNF-α and VEGF plasma levels. Despite the fact that NAX014 had no effect on swelling-infiltrating lymphocytes, it was found that mice doctored with NAX014 had lower levels of circulating TNF- and VEGF. The NAX014 compound is argued in the context of the overall judgments as a potential tool for therapeutic approaches against conscience cancers that overexpress HER-2.

Author(s) Details:

Elisa Pierpaoli,
Advanced Technology Center for Aging Research, Scientific Technological Area, IRCCS INRCA, 60121 Ancona, Italy.

Francesco Piacenza,
Advanced Technology Center for Aging Research, Scientific Technological Area, IRCCS INRCA, 60121 Ancona, Italy.

Gaetano Fiorillo,
Naxospharma Srl, 20026 Novate Milanese, Italy.

Paolo Lombardi,
Naxospharma Srl, 20026 Novate Milanese, Italy.

Fiorenza Orlando,
Experimental Animal Models for Aging Unit, Scientific Technological Area, IRCCS INRCA, 60121 Ancona, Italy.

Carmela Salvatore,
Aesis Therapeutics Srl, Incubatore JCube, 60035 Jesi, Italy.

Cristina Geroni,
Aesis Therapeutics Srl, Incubatore JCube, 60035 Jesi, Italy.

Mauro Provinciali,
Advanced Technology Center for Aging Research, Scientific Technological Area, IRCCS INRCA, 60121 Ancona, Italy and Experimental Animal Models for Aging Unit, Scientific Technological Area, IRCCS INRCA, 60121 Ancona, Italy.

Please see the link here: https://stm.bookpi.org/PRAMR-V2/article/view/9016

Study on Transduodenal Migration of Pancreatic Duct Stent into Liver | Chapter 14 | Issues and Developments in Medicine and Medical Research Vol. 9

 Endoscopic Retrograde Cholangio-pancreatography (ERCP) is a procedure that involves dilatation and stent insertion to treat symptomatic pancreatic duct obstruction. There hasn't been any reports of a duodenal perforation induced by pancreatic plastic stent migration into the liver. Perforative peritonitis occurs when the contents of the intestine leak into the peritoneal cavity. Stent migration leading to duodenal perforation, on the other hand, is a sluggish process in which inflammation forces adjacent organs to attach, preventing intestinal contents from leaking into the open peritoneal cavity. A case of duodenal perforation induced by pancreatic stent migration into the liver is presented.

Author(S) Details

D. Samprathi
Department of General Surgery, Grant Government Medical College and JJ Group of Hospitals, Mumbai, Maharashtra, India.

View Book:- https://stm.bookpi.org/IDMMR-V9/article/view/5849

A Qualitative Study on Migrant Labourers in Idukki District, Kerala| Chapter 10 | Selected Topics in Humanities and Social Sciences Vol. 4

 For disadvantaged people all around the world, migration is seen as a vital source of income. It cannot be reduced to a simple reaction to challenges and issues in the context of a certain country or place of origin. In India, migrant workers have grown to be a substantial economic force. Kerala, India, has a considerable influx of migrant labourers from all across the country, including West Bengal, Tripura, Assam, Bihar, Uttar Pradesh, Odisha, Maharashtra, and Tamil Nadu. Outmigration from Kerala to other countries is increasing due to improved education options and qualifications, as well as a scarcity of unskilled/semi-skilled employees inside the state. Internal relocation to Kerala is boosted by opportunities with fair salaries and life situations, as well as non-discriminatory attitudes and behavioural patterns among its inhabitants. The primary goal of this research is to look at the current and future consequences of large-scale interstate migration in rural areas. Based on a sample survey of 140 households in Idukki District and literature reviews, this study on inter-state migration in Kerala sheds light on many topics including migration, mobility, and sustenance. It looks at the diaspora situation, or migration patterns, from a variety of angles, including demographic, economic, and socio-political factors. It's a high-quality analgesic.

Author (S) Details

Jijo James Indiparambil
Sanjo College (SCMAS), Rajakkad, India.

View Book :- https://stm.bookpi.org/STHSS-V4/article/view/2863

Study of Migrations as a Public Health Issue | Chapter 2 | New Frontiers in Medicine and Medical Research Vol. 1

 Migrations are temporary or permanent changes of residence, and migrants are people who temporarily or permanently leave their home or country, depending on whether they are internal or external migrations. Economic, political, natural calamities, and wars are all reasons for migration. Around 3.6 percent of the world's population lives outside their home country, and the number of migrants is steadily increasing, with an anticipated 405 million migrants in the world by 2050. Migrations result in the spread of infectious and non-communicable diseases among migrants and the local population in the countries they transit through or stay in.

The goal is to emphasise the importance of migration as a public health issue that impacts both migrants and local residents.

Methods: Review of scientific literature and reports from relevant institutions on the impact of migration on illness occurrence in populations.

Migrants are of all ages, with the exception of the elderly, and are of both sexes, albeit men are more likely to leave their home country for various reasons. Children who relocate without a parent or guardian pose a unique challenge. Personal characteristics of migrants, motives for movement, modes of travel, migration season, hygienic and sanitary conditions in the places through which migrants pass, and conditions at the final destination all influence the occurrence of diseases among migrants. Economic migration has the least negative influence on health since it is planned, migrants are provided with adequate transportation, and they are able to work and live in their final destination. Unplanned migrations, whether prompted by wars, natural disasters, or political factors, have a significant negative influence on health. These migrants' health is jeopardised because they travel by dangerous modes of transportation, lack documentation, including health identity cards, cross borders illegally, and stay unlawfully in transit and host countries. This group of migrants does not have suitable housing. They are constantly stressed, which impacts the start of sickness, because they do not have proper access to health care. Infectious diseases are easily disseminated among migrants, and they are also transmitted to the local population, because they live in groups. Migrants typically have late diagnoses of infectious and non-infectious disorders as a result of an insufficient approach to health care. As a result, treatment is frequently delayed. Linguistic and cultural hurdles obstruct migrants' ability to exercise their rights.

Conclusion: Migration is a major public health issue in today's world, and it needs to be tackled in a methodical manner with the participation of the entire community.

Author (s) Details

Obradovic Zarema
Faculty for Health Studies, University of Sarajevo, Bosnia and Herzegovina.

View Book :- https://stm.bookpi.org/NFMMR-V1/article/view/2781

Epigenetic Sensitisation of Chemotherapeutic Compounds in Non- Small Cell Lung Cancer | Book Publisher International

 Lung cancer is now the leading cause of cancer-related death worldwide, with 1.7 million fatalities in 2018. The most common kind of lung cancer is non-small cell carcinoma (NSCLC), which accounts for about 80% of all occurrences. In most countries, chemotherapy is still the first-line treatment for NSCLC patients. Chemotherapy is expected to be utilised for at least another two decades, despite the development of novel medicines (targeted chemicals, immunotherapy). Chemotherapy resistance is one of the key variables contributing to lung cancer mortality, and it has been well established in preclinical investigations and clinical trials to date. Currently, there are only a few biomarkers for predicting chemotherapy efficacy, most of which are clinical. Furthermore, clinically, sensitization of cancer cells to such chemicals is largely useless. This research looks into new ways for lung cancer cells to become sensitive to four standard chemotherapeutics (cisplatin, carboplatin, gemcitabine, and vinorelbine), with a focus on epigenetics and the involvement of extracellular vesicles. Cloning, inducible transgene expression, shRNA-based silencing, proliferation and apoptosis assays, the neutral comet assay, RT-qPCR, pyrosequencing-based DNA methylation analysis, and other molecular and cell biology methods (cloning, inducible transgene expression, shRNA-based silencing, proliferation and apoptosis assays, the neutral comet assay, RT-qPCR I examined a wide range of factors in connection to drug resistance in NSCLC cell lines (e.g., western blots, EV isolation and characterization). Resistant cell lines were chosen for sensitization with epigenetic medicines (VPA and DAC), aminomethylphosphonic acid (AMPA), and fendiline after the IC50 of each of the four medications was determined in eight NSCLC cell lines.

VPA showed strong chemotherapeutic sensitization potential for all four chemotherapeutics, which is a first for lung cancer cells. In cells treated with cisplatin or carboplatin, both VPA and DAC caused a considerable increase in apoptotic activity. Gemcitabine produced double strand DNA breaks in the NSCLC cell lines A549, CALU-6, and COR-L23, and pre-treatment with VPA amplified this impact, which was also a novel discovery in this investigation.

I also looked at the role of LANCL1-AS1, a long-noncoding RNA that was shown to be reduced in NSCLC tissues by our research team. Following the establishment of an inducible expression model in the SK-MES-1 cell line, it was discovered that LANCL1-AS1 induced an increase in proliferation rate, migration invasion, sensitivity to gemcitabine and vinorelbine, increased resistance to platin compounds, and, most notably, expression of its coding counterpart gene, LANCL1. The LANCL1 shRNA-based silencing resulted in a reduction in proliferation, migration, and oxidative stress sensitivity. However, sensitivity to all four medications followed the same pattern as overexpression of LANCL1-AS1, raising doubts about whether these two activities are connected or separate, with no way to rule out the possibility of off-target effects from the shRNA method at this time.

The function of extracellular vesicles (EVs) in cancer development and medication resistance has just lately been studied. As a result, I decided to see if the LANCL1-AS1-dependent gemcitabine sensitivity could be transferred to EVs. Increased LANCL1-AS1 expression resulted in a dose-dependent increase in EV release. Unfortunately, due to a variety of technical concerns with the EV isolation reagent's toxicity, knowledge of how LANCL1-AS1 produced EVs affect gemcitabine resistance when transmitted to a recipient cell line was not possible. Finally, this research has revealed some new insights towards sensitising NSCLC cells in a preclinical setting. More research is needed to determine whether these findings are clinically useful and how they might alter lung cancer treatment.

Author(s) Details

Ghaliah Obaid F. Alnefaie
Medical Genetic Department, Taif University, Taif, Saudi Arabia.

View Book:- https://stm.bookpi.org/ESCCNSCLC/article/view/1837

Advanced Study on Resource-Saving Methods of Forming Information Infrastructure of Sorting Stations | Chapter 3 | New Ideas Concerning Science and Technology Vol. 4

 This chapter explores a resource-saving method for choosing the rational structure of an automated control system while migrating the technological structure from a powerful processor-based centralized system to a functionally distributed microcontroller-based system. The method helps you to decide a reasonable number of subsystems that efficiently utilize the computational and financial resources of the project. A real instance of designing an electronic control system for a marshalling yard shows the approach.

Author (s) Details

Anatolii  Kosolapov
Computer Department, Dnipro National University of Railway Transport, Dnipro, Ukraine.

View Book :- https://stm.bookpi.org/NICST-V4/issue/view/13