Background: Tamarindus indica leaves have been traditionally
used to manage pain, inflammation, and disorders of the nervous system.
Different parts of plants—including leaves, fruit pulp, bark, and seeds—are
traditionally used to treat fever, gastrointestinal disorders, inflammation,
pain, and various infections. Scientific evidence supporting these uses is
limited, prompting an evaluation of their pharmacological activities in
experimental models.
Aim: The present study aimed to evaluate the pharmacological
effects of Tamarindus indica leaf extract, specifically its analgesic,
anti-inflammatory, and central nervous system (CNS) depressant activities, in
order to assess its potential therapeutic applications.
Methods: Fresh leaves of T. indica were collected from the
campus of the University of Rajshahi, Bangladesh. An aqueous extract of T.
indica leaves was administered to mice at doses of 50 mg/kg and 100 mg/kg.
Analgesic activity was assessed using the acetic acid–induced writhing test.
Anti-inflammatory effects were measured through carrageenan-induced paw oedema.
Central nervous system (CNS) depressant activity was examined using the Open
Field and Hole Cross tests to determine changes in locomotor and exploratory
behaviours.
Results: The extract produced significant, dose-dependent
analgesic effects, with 100 mg/kg showing 77.94% inhibition of writhing,
comparable to the standard drug (83.33%). Anti-inflammatory activity also
increased with dose and time, with notable suppression of paw oedema at later
phases of inflammation. In CNS activity tests, both doses—particularly 100
mg/kg—significantly reduced movement and exploratory behaviours, indicating
strong CNS depressant action.
Conclusion: T. indica leaf extract exhibits potent
analgesic, anti-inflammatory, and CNS depressant properties in mice. These
effects may involve modulation of inflammatory pathways and central
neurotransmitter systems such as GABA. The results support traditional uses of
the plant and highlight its potential for future development of natural
therapeutic agents. Further studies are needed to identify active compounds and
clarify their mechanisms of action.
Author(s) Details
KHADIZA KHANAM
Department of Pharmacy, Varendra University, Rajshahi, Bangladesh.
A. H. M. MOSTOFA
KAMAL
Rajshashi Medical College Hospital, Rajshahi, Bangladesh.
MOSTAFIZUR RAHMAN
Department of Pharmacy, Varendra University, Rajshahi, Bangladesh.
SHAMMI AKHTER
Department of Pharmacy, Varendra University, Rajshahi, Bangladesh.
SIMIN SHABNAM LOPA
Department of Pharmacy, Varendra University, Rajshahi, Bangladesh.
MD. ATIKUL ISLAM
Department of Pharmacy, Varendra University, Rajshahi, Bangladesh.
MD. SARWAR JAHAN
Department of Pharmacy, Varendra University, Rajshahi, Bangladesh.
NURUNNAHAR
Department of Pharmacy, Varendra University, Rajshahi, Bangladesh.
Please see the book here :- https://doi.org/10.9734/bpi/psnid/v9/6722
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