Paediatric multisystem inflammatory syndrome (MIS-C),
temporally linked to SARS-CoV-2 infection, emerged in 2020 as a condition of
significant clinical concern due to its potential to cause multiorgan
dysfunction and severe outcomes. It is a post-infectious phenomenon
characterised by a dysregulated immune response and intense systemic
inflammation. This review analyses scientific findings from the past decade,
with emphasis on advances in pathophysiology, updated diagnostic criteria,
epidemiological changes over the course of the pandemic, diversity of clinical
manifestations, therapeutic strategies, and future perspectives. In 2020, the
first cases of MIS-C were diagnosed as Kawasaki disease, and after changes,
like Kawasaki disease. The documented experience of a second-level hospital in
Guanajuato, Mexico, is also incorporated, allowing reflection on diagnostic and
therapeutic challenges in middle-resource settings. Although incidence has
decreased following the circulation of recent variants and the implementation
of vaccination, MIS-C continues to represent a challenge for global
paediatrics.
Author(s) Details
Juan Pablo
Martínez-Becerra
Department of Research and Technological Development, Directorate of
Teaching and Research, Institute of Public Health from Guanajuato State,
Guanajuato, México.
Miztli David
Aguilar-Caballero
Department of Research and Technological Development, Directorate of
Teaching and Research, Institute of Public Health from Guanajuato State,
Guanajuato, México.
Ma Guadalupe
León-Verdín
Department of Research and Technological Development, Directorate of
Teaching and Research, Institute of Public Health from Guanajuato State,
Guanajuato, México.
María de Jesús
Gallardo-Luna
Department of Research and Technological Development, Directorate of
Teaching and Research, Institute of Public Health from Guanajuato State,
Guanajuato, México.
Efraín Navarro-Olivos
Directorate of Teaching and Research, Institute of Public Health from
Guanajuato State, Guanajuato, México.
Leticia Zamora-Ramos
General Directorate of Medical Care, Institute of Public Health from
Guanajuato State, México.
Nicolás
Padilla-Raygoza
Department of Research and Technological Development,
Directorate of Teaching and Research, Institute of Public Health from
Guanajuato State, Guanajuato, México.
Please see the book here :- https://doi.org/10.9734/bpi/aodhr/v8/6525
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