Construction of a series of N'-arylidene-3-(4-phenyloxazol-2-yl)propanehydrazide
4a–4j was achieved through the development of an easy, effective, and
environmentally safe method. Under moderate reaction conditions, each substrate
was obtained in good yield. IR, 1H NMR, 13C NMR, and mass analysis were used to
characterize each prepared hydrazone. Moreover, an antimicrobial activity
screen was conducted on compounds 4a–4j. The prepared compounds' anti-microbial
properties were tested against four bacterial strains Bacillus cereus, Bacillus
megaterium, Escherichia coli, Xanthomonas campestris, and Candida albicans.
Compounds 4i, 4f, and 4a demonstrated superior activity against Xanthomonas
campestris, the compounds 4j, 4a, and 4h demonstrated good activity against
Bacillus megaterium, the compounds 4a–4j display moderate activity against
Escherichia coli, and Candida albicans.
Author(s)
Details
S.
Aravind
Department of Chemistry, University College of Science, Saifabad,
Osmania University, Hyderabad, Telangana, India.
T.
Somasekhar
Department of Natural Products & Medicinal Chemistry,
CSIR-Indian Institute of Chemical Technology Tarnaka, Hyderabad, Telangana,
India.
T.
Kiran Kumar
Department of Natural Products & Medicinal Chemistry,
CSIR-Indian Institute of Chemical Technology Tarnaka, Hyderabad, Telangana,
India.
Surinderpal
Singh
Department of Chemistry (H&S), CMR Engneering College,
Kandlakoya, Hyderabad, Telangana, India.
B. S.
N. Murthy
Department of Chemistry, Sir C R Reddy College, Eluru, Andhra
Pradesh, India.
K. A.
Emmanuel
Department of Chemistry, Y.V.N.R Government Degree College,
Kaikaluru, Andhra Pradesh, India.
G. Giri
Prasad
Department of Chemistry, A.G & S.G. Siddartha Degree College
of Arts and Science, Vuyyuru, Andhra Pradesh, India.
Please see the book here:- https://doi.org/10.9734/bpi/rdcbr/v5/1418
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