Preparation and Antimicrobial Evaluation of N'-arylidene-3-(4-phenyloxazol-2 yl)propanehydrazides| Chapter 6 | Recent Developments in Chemistry and Biochemistry Research Vol. 5

 

 

Construction of a series of N'-arylidene-3-(4-phenyloxazol-2-yl)propanehydrazide 4a–4j was achieved through the development of an easy, effective, and environmentally safe method. Under moderate reaction conditions, each substrate was obtained in good yield. IR, 1H NMR, 13C NMR, and mass analysis were used to characterize each prepared hydrazone. Moreover, an antimicrobial activity screen was conducted on compounds 4a–4j. The prepared compounds' anti-microbial properties were tested against four bacterial strains Bacillus cereus, Bacillus megaterium, Escherichia coli, Xanthomonas campestris, and Candida albicans. Compounds 4i, 4f, and 4a demonstrated superior activity against Xanthomonas campestris, the compounds 4j, 4a, and 4h demonstrated good activity against Bacillus megaterium, the compounds 4a–4j display moderate activity against Escherichia coli, and Candida albicans.

 

Author(s) Details

S. Aravind

Department of Chemistry, University College of Science, Saifabad, Osmania University, Hyderabad, Telangana, India.

T. Somasekhar
Department of Natural Products & Medicinal Chemistry, CSIR-Indian Institute of Chemical Technology Tarnaka, Hyderabad, Telangana, India.

T. Kiran Kumar
Department of Natural Products & Medicinal Chemistry, CSIR-Indian Institute of Chemical Technology Tarnaka, Hyderabad, Telangana, India.

Surinderpal Singh
Department of Chemistry (H&S), CMR Engneering College, Kandlakoya, Hyderabad, Telangana, India.

B. S. N. Murthy
Department of Chemistry, Sir C R Reddy College, Eluru, Andhra Pradesh, India.

K. A. Emmanuel

Department of Chemistry, Y.V.N.R Government Degree College, Kaikaluru, Andhra Pradesh, India.

G. Giri Prasad
Department of Chemistry, A.G & S.G. Siddartha Degree College of Arts and Science, Vuyyuru, Andhra Pradesh, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/rdcbr/v5/1418

Role of Pyridine Containing Azetidinone Derivatives as Privileged Scaffolds in Anti Tubercular Agents | Chapter 9 | Technological Innovation in Pharmaceutical Research Vol. 11

In the current study, we synthesised a novel series of 3-Chloro-1-phenyl-4-(pyridine-4yl-)azetidin-2-one derivatives using Schiff base as an intermediary in the quest for prospective Tuberculosis treatments. The resulting Schiff base is then eliminated, resulting in named Azetidinone derivatives. Nucleophilic addition followed by elimination is the mechanism involved in the production of Schiff base. The newly produced Schiff base is then cyclized to produce novel Azetedinone derivatives. The named compounds were physically examined and structurally investigated using spectroscopic methods (IR, 1H-NMR, MASS). The chemicals Azt-1 to Azt-6 were tested for anti-tubercular activity in vitro. The Micro plate Alamar Blue Assay (MABA) method was used to test anti-tubercular activity in vitro. Azt-1(H), Azt-2(Cl), Azt-5 (O-OH), and Azt-6 (P-OH) were the most active compounds in the series compared to standards. The presence of electron withdrawing group -Cl, (Azt-2) and electron donating substituents -OH at ortho and para positions in the phenyl ring of (Azt-5) and (Azt-6) respectively could explain the potent anti tubercular activity.

Author (S) Details

N. Pramod
Department of Pharmaceutical Chemistry, A.G.M College of Pharmacy, Varur-581207, Hubli, Karnataka, India.

C. Bharath Kumar
Department of Pharmaceutical Chemistry, Annamacharya College of Pharmacy, Rajampet-516126, Kadapa, Andhra Pradesh, India.

P. Sri Lekha
Department of Pharmaceutical Chemistry, Institute of Pharmaceutical Technology, SPMVV, Tirupati-517502, Andhra Pradesh, India.

B. Mayuri
Department of Pharmaceutical Chemistry, Annamacharya College of Pharmacy, Rajampet-516126, Kadapa, Andhra Pradesh, India.

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