Synthesis and Characterization of N,N-Dimethyl Aminophenyl Schiff’s Base-Chalcone Hybrid by In-silico and In-vitro Studies | Chapter 8 | Current Research Progress in Physical Science Vol. 3

The two biological active scaffolds (chalcone and Schiff base) were combined in a single compound by the simple synthetic methodology. Nuclear Magnetic Resonance (NMR), Fourier Transform – Infra Red (FT-IR), Ultraviolet (UV)-visible spectroscopy, and mass spectrophotometer techniques were used to characterize the synthesised compound. The reactivity of these compounds was theoretically revealed using Density Functional Theory (DFT) calculations such as Frontier Molecular Orbital (FMO), Mullikan charge distribution and molecular electrostatic potential (MEP) mapping studies by the use of Density Functional Theory (DFT) calculations, such as Frontier Molecular Orbital (FMO), Mullikan charge distribution, and molecular electrostatic potential (MEP) mapping studies, was revealed the reactivity of these compounds theoretically. Furthermore, the enzymes such as 1PGG.pdb, 4COX.pdb, and 1HNY.pdb which cause inflammation and diabetes were also carried out by molecular docking studies. In addition to that in-vitro activity of the inflammation and diabetes was also executed and results were compared with standard drug molecules. Schiff base ligands and their metal complexes have a wide range of applications reported so far. These complete theoretical and experimental studies could provide more functional details of the compounds in the wide applications of biological studies.

 

Author(s) Details

 

Rajendran Nithyabalaji
Department of Physics, SRM Valliammai Engineering College, Kattankulathur, Kanchepuram Dt., Tamil Nadu, India.

 

Ramya Rajan M. P.
Department of Physics, SRM Valliammai Engineering College, Kattankulathur, Kanchepuram Dt., Tamil Nadu, India.

 

Rengarajan Kavitha
Department of Physics, Rajalakshmi Institute of Technology, Poonathamalee, Chennai, Tamil Nadu-6000124, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/crpps/v3/2021

 

Synthesis and Characterisation of 2-Acetylbenzothiophene-Based Semicarbazone Ligands | Chapter 4 | Chemistry and Biochemistry: Research Progress Vol. 7

Two semicarbazone ligands, 2-acetylbenzothiophene-3-semicarbazone (Hbtsc) and 2-acetylbenzothiophene-4-phenyl-3-semicarbazone (Hbtpsc), were synthesised via condensation reactions of semicarbazide derivatives with 2-acetylbenzothiophene. The 2-acetylbenzothiophene scaffold was chosen because of its heteroaromatic core, which is rich in electrons and is known to improve conjugation and bioactivity. Because of their biological significance and adaptable coordination behaviour, semicarbazones are the subject of extensive research. FT-IR, UV-Vis, ¹H and ¹³C NMR spectroscopy, elemental analysis, and single crystal X-ray diffraction (for b) were all used to completely characterise the ligands. Spectroscopic data confirmed the keto tautomeric form of both ligands in the solid state. IR spectra showed characteristic ν(C=N) and ν(C=O) stretching vibrations around the range of 1587-1536 cm⁻¹ and 1753-1682 cm⁻¹, respectively. Signals at δ around 10 ppm and 6–8 ppm in the ¹H NMR spectra were attributed to N–H and aromatic protons, which is in line with the keto tautomer. Electronic spectra displayed broad absorptions at 315–318 nm due to n→π* transitions. Single crystal structural analysis of b revealed a triclinic unit cell with P1 space group and two independent molecules (Z′ = 2) in the asymmetric unit. The molecules adopt an E-configuration across the C=N bond, and C=O bond lengths of 1.235 and 1.221 Å, confirming the presence of the keto form. The structure was stabilised by intramolecular hydrogen bonding and weak C–H···π interactions, which contribute to the formation of a stable zigzag packing arrangement. These structural insights provide a foundation for potential future applications in coordination chemistry and materials science.

 

Author(s) Details

Safa Faris Kayed
Department of Chemistry, College of Science and Humanities in Al-Kharj, Prince Sattam bin Abdulaziz University, Al-kharj 11942, Saudi Arabia and Department of Chemical Sciences, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia.

 

Yang Farina
Department of Chemical Sciences, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia.

 

Please see the book here:- https://doi.org/10.9734/bpi/cbrp/v7/5860

Formation and Analysis of Cobalt (III) with a Tetradentate N,N,O,O-Donor Ligand and 2,2'-{Propane-1,2-diyl-bis[Nitrilo(E) Methylidene]}bis(6-Methoxyphenol) | Chapter 5 | Chemical and Materials Sciences: Developments and Innovations Vol. 10

For a long time, chelating agents derived from organic compounds containing N,S,O-donor as a functional group have a strong ability to form metal complexes and exhibit a variety of biological activities. A number of studies have been done on the various Schiff base complexes formed by the condensation of secondary amines with different aldehydes and ketones. Schiff bases have often been used as chelating ligands in the field of coordination chemistry, and their metal complexes have been extensively investigated due to their potential applications. It is known that reactions of N,N,O,O-donor Schiff base ligands with transition metal ions have produced a series of complexes with interesting structures and magnetic properties. A new complex prepared by the reaction of 2,2'-{propane-1,2- diyl-bis[nitrilo(E)methylidene]}bis(6-methoxyphenol) (H2L) with Co(III) ion is reported in this paper. The bicompartmental ligand acts in a tetradentate fashion. The H2L ligand is structurally characterized by elemental analysis, NMR and infrared spectroscopies, conductance and single X-ray diffraction.

The compound with Co(III) crystallizes in the monoclinic system in the space group P2₁/c with the unit cell parameters a = 13.168(2) Å, b = 15.795(2) Å, c = 15.882(2) Å, α = 90°, β = 110.703(16)°, γ = 90°. The cobalt (III) ion has a slightly distorted octahedral coordination geometry.

In the structure of the mononuclear complex, the Co(III) cation is coordinated by two imine nitrogen atoms, two phenoxo oxygen atoms, from deprotonated Schiff base ligand and two oxygen atoms of water. There are also neighboring two molecules of DMF and one perchlorate anion non-coordinating. The study concluded that the structure revealed tetradentate coordination of the ligand via two nitrogen atoms and two deprotonated phenolicoxygen atoms. In this complex, the central metal center is hexacoordinated. This complex is characterized by spectroscopic studies (IR, NMR), molar conductivity and X-ray diffraction.

 

Author (s) Details

Alassane Saidou Diallo
Department of Chemistry, UFR SATIC, Alioune DIOP University, Bambey, Senegal.

 

Mariama Sarr
Department of Chemistry, UFR SATIC, Alioune DIOP University, Bambey, Senegal.

 

Mbosse Ndiaye Gueye
Department of Chemistry, Cheikh Anta Diop University, Dakar, Senegal.

 

Antoine Blaise Kama
Department of Chemistry, UFR SATIC, Alioune DIOP University, Bambey, Senegal.

 

Farba Bouyagui Tamboura
Department of Chemistry, UFR SATIC, Alioune DIOP University, Bambey, Senegal.

 

Ibrahima Elhadj Thiam
Department of Chemistry, Cheikh Anta Diop University, Dakar, Senegal.

 

Moussa Dieng
Department of Chemistry, UFR SATIC, Alioune DIOP University, Bambey, Senegal.

 

Mohamed Gaye
Department of Chemistry, Cheikh Anta Diop University, Dakar, Senegal.

 

Please see the book here:- https://doi.org/10.9734/bpi/cmsdi/v10/4156

Ionic Liquid-based Schiff Base Ligand for the Synthesis of Fe(III) and Cr(III) Metal Complexes and Their Antibacterial Studies | Chapter 5 | Recent Developments in Chemistry and Biochemistry Research Vol. 2

Fe(III) and Cr(III) complexes derived from an ionic liquid-based Schiff base, 1-{2-(2-hydroxy-5-chlorobenzylamine)ethyl}-3-ethylimidazolium were characterized and established by various analytical and spectroscopic techniques such as ESI-MS, UV-Visible, FT-IR, 1H NMR, elemental analysis and magnetic susceptibility measurements. Based on these spectral data octahedral geometry was suggested for the both complexes. The Schiff base ligand and its complexes were screamed for in vitro antibacterial activities against gram positive and gram negative bacteria to assess their effects. Cr(III) complex showed higher activity than the Fe(III) complex against the tested gram positive and gram negative bacteria.

Author(s) Details:

Sanjoy Saha,
Department of Chemistry, Kaliyaganj College, Kaliyaganj-733109, India.

Please see the link here: https://stm.bookpi.org/RDCBR-V2/article/view/14113

Evaluation of Schiff Bases Derived from 1,8-diaminonaphtalène: An Approach towards Its Synthesis, Characterization and Biological Activities | Chapter 7 | Current Topics and Emerging Issues in Chemical Science Vol. 2

 This episode evaluates the synthesis, Characterization and Biological Activity of Schiff Bases arisen 1,8-diaminonaphtalène.  Schiff bases are the most usual organic compounds. They have existed proved to exhibit a broad range of biological projects, including antifungal, completely clean, antimalarial, antiproliferative, anti-angering, antiviral, and antipyretic properties. Salicylaldehyde, Ortho-Vanilline, and benzene-1,8-diaminonaphtalene were acquired from Aldrich and used outside further purification. The compound have happened synthesized and from routine MS, IR and NMR spectrometry arrangements. The compounds are all active on bacterial strains other than Salmonella typhimirium, with a MIC profit of 7.5 mg / mL. They show a percentage of antagonistic-radical activity of 75.476 ± 5.070 for the compound DAN-S and of 68.142 ± 6.539 for the compound DAN-OV. The less substituted DAN-S compound is more alive as shown in the graph resembling pie. For these molecules, this is the first occasion, our information, that such main antioxidant properties have happened observed.

Author(s) Details:

Kangah Niameke Jean Baptiste,
Laboratoire de Thermodynamique et de Physico-Chimie du Milieu, UFR SFA, Universite Nangui Abrogoua, Abidjan, Cote d’Ivoire.

Tuo Nanou Tieba,
Laboratoire de Thermodynamique et de Physico-Chimie du Milieu, UFR SFA, Universite Nangui Abrogoua, Abidjan, Cote d’Ivoire.

Ballo Daouda,
Laboratoire de Chimie Organique Heterocyclique URAC 21, Pole de Competence Pharmacochimie, Faculte des Sciences, Universite’ Mohammed V, Rabat, Morocco and Laboratoire de Constitution et Reaction de la Matiere (LCRM), UFR Sciences des Structures de la Matiere et Technologie, Universite Felix Houphouet-Boigny, Abidjan, Cote d’Ivoire.

Kablan Ahmont Landry Claude,
UFR Des Sciences Biologiques, Universite Peleforo Gon Coulibaly de Korhogo, Korhogo, Cote d’Ivoire.

Kouame N’goran Etienne,
Laboratoire de Thermodynamique et de Physico-Chimie du Milieu, UFR SFA, Universite Nangui Abrogoua, Abidjan, Cote d’Ivoire.

Kodjo Charles Guillaume,
Laboratoire de Thermodynamique et de Physico-Chimie du Milieu, UFR SFA, Universite Nangui Abrogoua, Abidjan, Cote d’Ivoire.

Ziao Nahosse,
Laboratoire de Thermodynamique et de Physico-Chimie du Milieu, UFR SFA, Universite Nangui Abrogoua, Abidjan, Cote d’Ivoire.

Please see the link here: https://stm.bookpi.org/CTEICS-V2/article/view/11533

Recent Study on Synthesis, Characterization and Bioactivity Study of Bidentate NS Schiff Base of S-Benzyl Dithiocarbazate and its Zn (II) and Pd (II) Complexes | Chapter 1 | Current Topics on Chemistry and Biochemistry Vol. 9

 The another time-chelated four coordinate complexes (ML2, L = deprotonated ligand) of Zn(II) and Pd(II) ions  combined, were derived from a new bidentate NS Schiff base called S-benzyl-β-N-(4-hydroxy-3-nitrophenyl)methylene dithiocarbazate (HL), that is the condensation production of S-benzyl dithiocarbazate (SBDTC) with 4-hydroxy-3-nitrobenzaldehyde. The ligand and its aggregates were characterised using standard methods such as NMR, UV-apparent, IR, mass spectroscopy, magnetic susceptibleness measurement, and a hard bony structure in the jaws of vertebrates conductance. The projected crystal structure of the ligand was habitual by X-ray crystallography data from a alone crystal. The ligand exists in allure thione tautomeric form in both complete and solution points. The chelates were created by reacting the metal ions accompanying the azomethine nitrogen atom of the ligand and the deprotonated thiolate sulphur anion. Magnetic susceptibleness and electronic spectroscopic data submitted that the ZnL2 complex had a tetrahedral geometry, inasmuch as the PdL2 complex had a square planar makeup. Tail flick and carrageenan induced fondle edoema tests were used to assess the pain remover and anti-instigative activities of the ligand and its aggregates. When compared to the control, the ligand at 10 mg/kg caused a significant (***p < 0.001) increase in pain beginning in tail flick patterns, but it demonstrates moderate endeavor in complexes. When compared to the control, the ligand and composites significantly diminished paw edoema (***p< 0.001). Overall, these verdicts indicate that the ligand and its aggregates could be working as an effective anti-angering agent.

Author(s) Details:

Hasibul Islam,
Rajshahi Sugar Mills Ltd. (Uder Bangladesh Sugar and Food Industries Corporation, Ministry of Industries), Bangladesh, Rajshahi University of Engineering & Technology (RUET), Rajshahi-6204, Bangladesh and Polymer and Textile Research Lab, Department of Applied Chemistry and Chemical Engineering, University of Rajshahi, Rajshahi 6205, Bangladesh

Chanmiya Sheikh,
Department of Applied Science, Faculty of Science, Okayama University of Science, Japan.

Ryuita Myiatake,
Center for Environmental Conservation and Research Safety, Unversity of Toyama, 3190 Gofuku, Toyama, 930-8555, Japan.

Ronok Zahan,
Department of Pharmacy, University of Rajshahi, Rajshahi-6205, Bangladesh.

Al-Amin-Al-Azadul Islam,
Department of Chemistry, Rajshahi University of Engineering & Technology, Rajshahi-6204, Bangladesh.

Please see the link here: https://stm.bookpi.org/CTCB-V9/article/view/9752

Characterization and Synthesis of a Novel Schiff base Derived from 2-amino-5-(Substitutedphenyl) Thiadiazole, Substituted Aromatic Aldehyde and Acetyl Acetone: An Experimental Study| Chapter 1 | Progress in Chemical Science Research Vol. 5

We have created fresh Schiff bases. The ingredients 2-amino-5-(substituted phenyl) thiadiazole, substituted aromatic aldehyde, and acetyl acetone are used to create all targeted Schiff bases. In these procedures, a TBAHS catalyst supported by silica is utilised at a reflux temperature. The New Schiff bases were studied using mass spectroscopy, 1H NMR, and infrared technology.

Author(s) Details:

S. N. Ibatte,
Department of Chemistry, Dayanand Science College, Latur- 413512, (MS), India.

Please see the link here: https://stm.bookpi.org/PCSR-V5/article/view/8475

Role of Pyridine Containing Azetidinone Derivatives as Privileged Scaffolds in Anti Tubercular Agents | Chapter 9 | Technological Innovation in Pharmaceutical Research Vol. 11

In the current study, we synthesised a novel series of 3-Chloro-1-phenyl-4-(pyridine-4yl-)azetidin-2-one derivatives using Schiff base as an intermediary in the quest for prospective Tuberculosis treatments. The resulting Schiff base is then eliminated, resulting in named Azetidinone derivatives. Nucleophilic addition followed by elimination is the mechanism involved in the production of Schiff base. The newly produced Schiff base is then cyclized to produce novel Azetedinone derivatives. The named compounds were physically examined and structurally investigated using spectroscopic methods (IR, 1H-NMR, MASS). The chemicals Azt-1 to Azt-6 were tested for anti-tubercular activity in vitro. The Micro plate Alamar Blue Assay (MABA) method was used to test anti-tubercular activity in vitro. Azt-1(H), Azt-2(Cl), Azt-5 (O-OH), and Azt-6 (P-OH) were the most active compounds in the series compared to standards. The presence of electron withdrawing group -Cl, (Azt-2) and electron donating substituents -OH at ortho and para positions in the phenyl ring of (Azt-5) and (Azt-6) respectively could explain the potent anti tubercular activity.

Author (S) Details

N. Pramod
Department of Pharmaceutical Chemistry, A.G.M College of Pharmacy, Varur-581207, Hubli, Karnataka, India.

C. Bharath Kumar
Department of Pharmaceutical Chemistry, Annamacharya College of Pharmacy, Rajampet-516126, Kadapa, Andhra Pradesh, India.

P. Sri Lekha
Department of Pharmaceutical Chemistry, Institute of Pharmaceutical Technology, SPMVV, Tirupati-517502, Andhra Pradesh, India.

B. Mayuri
Department of Pharmaceutical Chemistry, Annamacharya College of Pharmacy, Rajampet-516126, Kadapa, Andhra Pradesh, India.

View Book :- https://stm.bookpi.org/TIPR-V11/article/view/3131

Biomedical Applications of Some Schiff Base Metal Complexes Containing Imidazole/Thiophene Derivatives | Chapter 5 | Current Advances in Chemistry and Biochemistry Vol. 9

 Schiff base was produced by condensing imidazole-2-carboxaldehyde with 2-amino-3-carboxyethyl-4,5-dimethyl thiophene in a 1:1 molar ratio. Schiff base complexes of CoII, NiII, CuII, and ZnII were produced and studied. Magnetic and electronic spectrum data were used to propose the complexes' shape. The thermal stability of the compounds was determined using thermal analysis. The fluorescence spectral study of the Schiff base and its CuII complex in various solvents was examined. The grain size was determined using powder XRD measurements. The surface morphology of the complexes is depicted in SEM pictures. The antibacterial and antifungal activity were tested using Kirby-disk Bauer's diffusion method. MTT assay was used to conduct in vitro anticancer investigations on a human cervical carcinoma cell line.

Author (s) Details

Dr. Sonia Mol Joseph
Department of Chemistry, Mar Ivanios College (Autonomous), Thiruvananthapuram, Kerala – 695 015, India.

R. Selwin Joseyphus
Department of Chemistry, Mar Ivanios College (Autonomous), Thiruvananthapuram, Kerala – 695 015, India.

View Book :- https://stm.bookpi.org/CACB-V9/article/view/2196

Synthesis and Characterization of Pd(II) Complex with Schiff Base Ligand: Suzuki-Miyaura Cross- Coupling Reaction | Chapter 7 | Current Perspectives on Chemical Sciences Vol. 5

It synthesises a new noble Pd(II) complex from . . Pd(Cod)Cl2 and a ligand for the Schiff base. FT-IR, UV-Vis, 1H and 13C NMR analyses characterise the complex. For the Suzuki-Miyaura cross-coupled reaction, the complex PdL measured the behaviour of aryl halides and boronic acids. At room temperature, the catalyst is found to be effective.

Author(s) Details

Rajjyoti Gogoi

Department of Chemistry, MDKG College, Dibrugarh, Assam, India.

View Book :- https://bp.bookpi.org/index.php/bpi/catalog/book/354