Background and Aim: The coexistence of immune thrombocytopenia
(ITP) and Crohn’s disease (CD) is not common. This review investigated studies
involving cases of concurrent ITP and CD.
Methods: A literature search and review of studies on patients
with comorbid ITP and CD, excluding those with drug- or vaccination-induced
ITP, was conducted.
Results: Of the 32 cases included in this review, 17 (53.1%) were
men, and 15 (46.9%) were women. Ten (31.3%) patients were initially diagnosed
with ITP, and 12 (37.5%) with CD. Meanwhile, 10 (31.3%) patients were
simultaneously diagnosed with ITP and CD. The development of ITP might be
associated with CD aggravation in some cases. The standard therapeutic
approaches for comorbid ITP and CD were glucocorticoids, intravenous
immunoglobulin, biologics, and splenectomy. However, ITP remission might be
achieved with bowel resection for CD. No fatalities were reported.
Conclusion: In the reported cases of comorbid ITP and CD, no clear
trends were observed regarding sex and preceding disease. Nevertheless, the
prognosis in these cases can be favourable.
Author(s)
Details
Toru
Shizuma
Department of Physiology, Tokai University School of Medicine,
143, Shimokasuya, Isehara, Kanagawa 259-1193, Japan.
Please see the book here:- https://doi.org/10.9734/bpi/aodhr/v5/6056
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