Introduction: Malnutrition is a major public health problem in all developing countries. Tuberculosis, an infectious disease caused by the bacteria Mycobacterium tuberculosis (MTB), is also a major cause of death in humans around the world. According to a World Health Organization (WHO) survey, MTB infects one-third of the world's population, with 9.6 million new tuberculosis (TB) infections and 1.5 million deaths confirmed in 2021. The progression of tuberculosis is highly dependent on the hosts' immunological status, and it requires the availability of micronutrients such as iron, zinc, and vitamins A and D to function properly.
Aim: The study of serum zinc levels and vitamin A levels in
tuberculosis patients.
Materials and Methods: This study included 40 newly diagnosed PTB
patients of both sexes with the age group of 18-60. The time period of this
study was from September 2020 to Арril 2021 а nоn-rаndоmized соntrоlled trial
was involved. Vitamin A was Estimated by the Colorimetric Method. EDTA samples
were used for the Hemoglobin, ES and WBC count was estimated on 3 parts coulter
counters. Albumins were estimated on AU480 Analyzer.
Results: There was a strong correlation between serum zinc and
vitamin A levels P < 0.01) Hb, P < 0.01) and serum albumin levels P <
0.01) were also strongly correlated with the vitamin A levels; however, WBC P
< 0.01) and ESR P < 0.01) were negatively correlated with the vitamin A
levels. Considering the significant role of Zn, its support may be effective in
resolving the disease. Until treatment, intermediate levels of serum Zn in
people with pulmonary TB were very low. The serum Zn level with the highest
decrease in stage 3, which was statistically significant, was a steady decline
in the number of people researching lung TB.
Conclusion: In view of the above, the patient's nutritional status
may be the most important determinant of infection tolerance. Zinc deficiency
can have an indirect impact on Vitamin A metabolism by reducing the levels of
circulating protein. Because of this, the addition of zinc in combination with
vitamin A may be helpful in achieving the disease status.
Author
(s) Details
Gangaram Bhadarge
Department of Biochemistry, Jawaharlal Nehru Medical College, Datta Meghe
Institute of Medical Sciences, Sawangi (Meghe), Wardha-442001, India.
Nandkishor Bankar
Datta Meghe Medical College, Nagpur, Datta Meghe Institute of Higher
Education and Research, India.
Sudhir Singh
Datta Meghe Medical College, Nagpur, Datta Meghe Institute of Higher
Education and Research, India.
Please see the book here:- https://doi.org/10.9734/bpi/psnid/v4/4715
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