This chapter presents the kinetic profiles of aldrin (AD) and its epoxide (= dieldrin, DD) in egg yolk to clarify their accumulation period and toxicity in chicken eggs. Laying hens were treated orally with a single dose of AD 1 mg/kg body weight. Concentrations (μg/g) of AD or DD in the yolk of eggs laid for 21 days after AD treatment were determined by normal phase HPLC. The limits of determination were 0.02 μg/g for AD and 0.03 μg/g for DD, respectively. After AD treatment, although the low levels of AD (mean 0.02–0.03 μg/g) were observed only during a three-day period (from 4th to 6th days), DD (mean 0.15 μg/g) was found already on the 2nd day, indicating that the epoxidation of AD to DD in the hen’s body is rapid. The highest level of DD (mean 0.40 μg/g) was detected on the 6th day, and then DD levels decreased slowly and were detected up to the 21st day. In this decreasing phase, the biological half-life of DD in the yolk was estimated to be 25.6 days. This study showed that in laying hens, AD, orally administrated, was rapidly metabolized to DD.
Author
(s) Details
N. FURUSAWA
Graduate School of Human Life & Ecology, Osaka Metropolitan University,
Osaka 558-8585, Japan.
Please see the book here:- https://doi.org/10.9734/bpi/cbrp/v4/4618
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