Liver injury is mainly caused by toxic chemicals, excess
consumption of alcohol, infections and autoimmune disorders. Most hepatotoxic
chemicals damage liver cells mainly by inducing lipid peroxidation and other
oxidative damage. The present study aimed at Evaluating Hepatoprotective
Activity with Leaf Extract of Alangium salvifolium Wang (Alangiaceae) on CCl4
induced Rats. Traditionally this plant is used in various types of liver
disorders and is also used as an antidiabetic, anticancer, diuretic, cardiotonic,
anti-inflammatory, antimicrobial, Laxative, epilepsy, antidote for poisonings,
burning sensation, constipation and haemorrhages.
The leaves of Alangium salvifolium were collected and prepared as ethanolic
extracts of Alangium salvifolium (ASEE), Silymarin, Ethanol, and CCl4, CMC,
Olive oil, analytical kits from standard companies. Albino Wistarrats(150-180
g) from TEENA Labs.
An acute toxicity study was conducted in animals to identify of LD50 value. Two
test doses were selected on the basis of LD50 and conducted Hepatoprotective
activity by using the CCl4-induced method. The collected blood samples were
subjected to various biochemical parameters (SGPT, SGOT, ALP, TB, ALB, TP and
CHOL). Dissected the liver for histopathological studies. The data were
statistically assessed by one-way analysis of variance (ANOVA) and subjected to
Dunnett’s test.
In hepatoprotective activity studies, the toxic group (CCl4) shows elevated
levels of SGPT, SGOT, ALP, CHOL and TBL whereas decreased TP and ALB levels
when compared with the control group. The pretreatment of ASEE at a dose of 150
and 300 mg/kg exhibited a reduction in the serum levels of SGPT(P<0.001),
SGOT(P<0.001), ALP(P<0.01), CHOL(P<0.01), TB(P<0.001), and elevated
the TP(P<0.01), ALB(P<0.001) levels when compared to toxic. ASEE of 300
mg/kg showed results similar to standard results. Histopathological studies
revealed that ASEE exhibited a remarkable recovery as Silymarin does. The
results of this study strongly indicate that leaves of Alangium Salvifolium
have potent hepatoprotective against CCl4. The hepatoprotective activity of
ASEE may be due to its free radical-scavenging and antioxidant activity,
resulting from the presence of flavonoids and triterpenoid compounds in the
extracts.
Author(s) Details:
Thatipelli Ravi Chander,
Vaagdevi Pharmacy College, Bollikunta, Warangal, India and Jawaharlal Nehru Technological University
Anantapur, Anantapur, India.
Yellu
Narsimha Reddy,
University
College of Pharmaceutical Sciences, Kakatiya University, Warangal, India.
Please see the link here: https://stm.bookpi.org/ACPR-V6/article/view/13410
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