Objectives: The purpose of the study was to investigate the
antioxidant and membrane stabilising potential of Globimetula oreophila leaves
in order to provide scientific support for the plant 's existing ethnomedicinal
or traditional uses. Methodology: The research included the collection,
identification, drying, spraying, extraction and fractionation of dried G leaf
extracts. Oreophila. Oreophil. In the assays (2,2-diphenyl-1-picrylhydrazyl
hydrate, nitric oxide, total antioxidant potential and ferric reducing
antioxidant power), the anti-inflammatory and antioxidant activities of the
extracts and fractions were evaluated using the red blood cell membrane
stabilisation technique.
Results: The findings showed that the extracts and the fractions of G. Oreophila
demonstrated high antioxidant activity. The highest antioxidant activity with
IC50 of 45.83 ± 0.13 μg / ml was shown in fraction 1 of the methanol extract,
while fraction 7 of the same extract was the most potent in stabilising
stressed red blood cells with 100 ± 0.00 percent stability of the membrane. The
operations of both the fractions and the G. extracts. Compared to regular
antioxidants and anti-inflammatory drugs, oreophila is optimistic. In addition,
the operations of the fractions and extracts are dependent on concentration.
Conclusion: The analysis showed that G's extracts and fractions. Oreophila has
and exhibits anti-inflammatory and antioxidant functions that are
concentration-dependent and beneficial compared with those of anti-inflammatory
nonsteroidal drugs. It could be concluded on the basis of these findings that
the extracts and the fractions of G. Oreophila includes oreophila, which Principles
capable of stabilising the exposure of bovine red blood cell membranes to heat
and hypotonic lyses could also serve as clinical evidence for the use of these
plant extracts by conventional local health professionals in the management and
treatment of inflammatory diseases.
Author (s) Details
Dr.
Esther O. Faboro
Department of Chemistry, Bowen University, Iwo, Nigeria.
Mr. Idowu J. Olawuni
Department of Biochemistry, Obafemi Awolowo University, Ile Ife, Nigeria.
Dr. Bolajoko A. Akinpelu
Department of Biochemistry, Obafemi Awolowo University, Ile Ife, Nigeria.
Professor Oluokun O. Oyedapo
Department of Biochemistry, Obafemi Awolowo University, Ile Ife, Nigeria
Professor Ezekiel O. Iwalewa
Department of Pharmacology and Therapeutics, University of Ibadan, Ibadan,
Nigeria.
Professor Craig A. Obafemi
Department of Chemistry, Obafemi Awolowo University, Ile Ife, Nigeria.
View Book :- https://bp.bookpi.org/index.php/bpi/catalog/book/282
No comments:
Post a Comment