In the metabolism of carbohydrates , lipids and proteins, the liver, as the central metabolic organ, plays an important role. There are several hepatotoxic xenobiotics present in the setting. CCl4 is a toxic free radical for hepatocyte organelles. The presented work investigated the characteristics of ultrastructural changes in CCl4-intoxicated hepatocytes as well as tissue after treatment with alpha-tocopherol (alpha-T) grape seed extract (GSE). The liver has a high regeneration potential as a consequence of the cell bioremediation effect and reactions against corrupting factors. Thus, the liver toxicity and LC models have a corrective impact based on the existence of ultrastructural changes in mitochondria and other hepatocyte compartments, GSE, as well as alpha-T and STS. The ultrastructural characterization of the GSE effect by TEM is proof of its effectiveness with cytoprotective and antitoxic features as well as xenobiotic-CCl4 hepatocytes caused by rat liver cirrhosis.
Author (s) Details
Karlen Hovnanyan
Scintific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences, Republic of Armenia.
Vardan Mamikonyan
Scientific and Technological Center of Organic and Pharmaceutical Chemistry, NAS RA, Yerevan, Armenia.
Anahit Margaryan
H. Buniatian Institute of Biochemistry, NAS RA, Yerevan, Armenia.
Kristine Sargsyan
Scintific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences, Republic of Armenia.
Margarita Hovnanyan
Scintific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences, Republic of Armenia.
Maria Karagyozyan
Scientific and Technological Center of Organic and Pharmaceutical Chemistry, NAS RA, Yerevan, Armenia.
Konstantin Karageuzyan
Scientific and Technological Center of Organic and Pharmaceutical Chemistry, NAS RA, Yerevan, Armenia.
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