Around 378 million individuals are
estimated by the WHO to be chronic carriers of HBV and many of them develop
progressive diseases, including cirrhosis and hepatocellular carcinoma. Genetic
variants have been suggested to be associated with an increased risk of
hepatocellular carcinoma caused by fulminant hepatitis B. The purpose of this
research was to examine mutations in the x gene region of patients infected
with HBV in the province of Golestan, Iran. In this study, 100 patients were
reported. The viral DNA of Hepatitis B was extracted from plasma and precise
primers were used to conduct PCR. 51 percent of the chronic HBV patients were
male. The findings showed that A1762 T, G1764A double mutations modifying AGG
to avoid codon TGA were present in 49 percent of patients. 27% and 24% of cases
displayed mutation only at positions A1762 T and G1764A, respectively. This
research revealed the existence of X gene mutations in patients infected with
chronic HBV in the province of Golestan, Iran. The frequency of HBV X gene
mutations in nucleotides of 1762 and 1764 was greater than that of nucleotides
of 1762 and 1764. The overall prevalence in the world (34 percent).
Author (s) Details
Sareh Zhand
Department of Microbiology, School of Medicine, Golestan University of
Medical Sciences, Gorgan, Iran.
Ghassem Rostamian
Department of Medicine, School of Medicine, Iran University of Medical
Sciences, Tehran, Iran.
Alijan Tabarraei
Department
of Microbiology, School of Medicine, Golestan University of Medical Sciences,
Gorgan, Iran.
Abdolvahab Moradi
Department of Microbiology, School of Medicine, Golestan University of Medical
Sciences, Gorgan, Iran.
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