Background: Kalanchoe luciae Raym-Hammet plant species is
generally used for the treatment of ear infections. Traditional health
practitioners use leaf juice extract directly from the leaves of K. luciae to
treat ear infections.
Aim of the Study: This study aims to evaluate the antifungal
properties of leaf extracts of K. luciae against Aspergillus fumigatus,
Cryptococcus neoformans, and Candida albicans.
Methodology: The plant species was selected from the
database of Ethnomedicinal Plants’ Laboratory, comprising over 300 medicinal
plants used for the treatment of various diseases in humans, Limpopo province,
South Africa. In this study, mature and young leaves of K. luciae were
extracted with acetone and methanol. The leaves were squeezed separately to
extract juice from the leaves. The leaf extracts were tested for antifungal
activity against Aspergillus fumigatus, Cryptococcus neoformans, and Candida
albicans using a serial dilution assay.
Results: The methanol and juice extracts had the highest
antifungal activity against A. fumigatus with minimum inhibitory concentrations
(MIC) of 0.04 and 0.10 mg/ml. C. neoformans was most susceptible to acetone
mature leaf extract, followed by both mature and young leaf extracts at a mean
MIC value of 0.09 mg/ml and 0.16 mg/ml, respectively. In the bioautography
assay, there were no active compounds observed in all extracts against the
tested fungal pathogens.
Conclusion: K. luciae can serve as a potential plant that
could be used as a source of antifungal compounds that can be incorporated into
antimicrobial drug production.
Author(s) Details
Sinorita Chauke
Department of Biodiversity, Faculty of Science and Agriculture, School of
Molecular and Life Sciences, University of Limpopo, Private Bag X1106, Sovenga,
0727, South Africa.
Salome Mamokone Mahlo
Department of Biodiversity, Faculty of Science and Agriculture, School of
Molecular and Life Sciences, University
of Limpopo, Private Bag X1106, Sovenga, 0727, South Africa.
Please see the book here :- https://doi.org/10.9734/bpi/aodhr/v7/5644
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