Background: Isoflavones are abundant in soy and other legumes, have established estrogenic properties, and had impressive biological effects in preclinical models. Isoflavones have been suggested as alternatives to hormone replacement therapy.
Objectives: This study evaluates the influence of
soy-enriched cookies on bone mineral density in perimenopausal women.
Methodology: A total of 36 women with perimenopausal older
than 40 years were enrolled for the 8 weeks of study, and participants of the
study were allocated into two groups, 18 participants in each group. Group G0
was the control group with no supplementation, and group G1 was the treatment
group with 40g soy flour cookies. The participants were selected from the
Orthopedic ward of Jinnah Hospital, Lahore. The 40g soy cookies were given to
the participants on a daily basis for 8 weeks. The study parameters such as
Vitamin D, Calcium, Phosphorus and BMD levels were measured at the start and
end of the study.
Results: The mean age of participants enrolled in this study
was 43.042±3.79 years in G0, and in G1 it was 42.45 ±4.45. The mean BMI was
24.2±3.10 and 22.50±2.50 kgm-2 in both groups, respectively after treatment,
with no statistical association. There was a significant change observed in
Vitamin D levels with values of 23.82±4.373 and 26.50±4.50, pre and
post-treatment respectively. Calcium levels improved significantly, rising from
11.52±3.01 to 12.00±2.85 with significant association (p-value less than 0.05).
On the other hand, Phosphorus levels also increased from 2.62 ± 0.75 to 3.00 ±
0.80 mg/dL. At the same time, BMD levels significantly (P<0.05) improved in
the treatment group from 0.727±0.09 to 0.800±0.1 with significant p-value.
Conclusion: In conclusion, the study demonstrated that
soy-enriched cookies significantly improve Vitamin D, calcium, phosphorus
levels and bone mineral density in perimenopausal women. These findings suggest
that incorporating soy flour cookies into the diet could be an effective
strategy for enhancing bone health and mineral metabolism in this population.
Author (s) Details
Maira Munir
The University of Lahore, Lahore, Pakistan.
Farah Khanum
The University of Lahore, Lahore, Pakistan.
Nudrat
The University of Lahore, Lahore, Pakistan.
Yusra Rasheed
The University of Lahore, Lahore, Pakistan.
Muntaha Jafar
The University of Lahore, Lahore, Pakistan.
Sara
The University of Lahore, Lahore, Pakistan.
Anam Aslam
The University of Lahore, Lahore, Pakistan.
Misbah Arshad
Staffordshire University, England.
Please see the book here:- https://doi.org/10.9734/bpi/aodhr/v2/5413
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