Microorganisms play an important role in causing inflammation in
the pulp and periapical regions. Even after undergoing chemo-mechanical
procedures during root canal treatment, bacteria may persist within dentinal
tubules, posing a risk of disease recurrence. Mineral trioxide aggregate (MTA),
introduced in 1993, has been investigated as a potential antibacterial material
since 1995. The MTA material is composed of minute hydrophilic particles that,
when exposed to water, undergo a process called colloidal gelation, which
builds a solid cement. Calcium and phosphorus are the primary ions in MTA, and
their antibacterial characteristics are attributed to the release of calcium
hydroxide through surface hydrolysis of calcium silicate components. Previous
studies have shown that MTA has limited antimicrobial properties. Several
alterations have been made to enhance the biological properties of MTA, such as
incorporating nanoparticles made from silver, zinc, gold and titanium.
Therefore, in this study, TiF4 was added to MTA in an effort to enhance its
antimicrobial properties. Titanium tetrafluoride (TiF4) has been extensively
examined in the field of dentistry for its potential applications: prevention
of dental caries, sealing of dentinal tubules in root canals, erosion
prevention, mitigation of dentinal hypersensitivity, and as an antibacterial
agent. This study compares and evaluates the antibacterial efficacy of MTA
after the incorporation of TiF 4. A green and fast synthesis method is used to
synthesize TiF 4. A total of 56 samples were made by mixing MTA with different
weight proportions of TiF4(1wt%, 2wt% and 3wt%).28 samples were taken to test
each of the following properties: antibacterial efficacy and pH. The specimens
were prepared using stainless steel molds of recommended dimensions for testing
the pH. The pH was evaluated using the pH meter and the antibacterial efficacy
using the direct contact test.
Data regarding antibacterial efficacy and pH of MTA with various
proportions of TiF4 were investigated for normality using the Kolmogorov
Smirnov test and assessed a normal distribution. The antibacterial properties
between the four groups were analyzed using One-way analysis of variance
(ANOVA) followed by pairwise multiple comparisons using Tukey’s Honest
significant difference test. The level of statistical significance was
determined at p ≤0.05.MTA when incorporated TiF4 showed enhanced antibacterial
properties. The group treated with MTA with 3% TiF4 had the highest mean values
of antimicrobial efficacy on day 1, with a mean of 4.67 ± 0.04 CFU/mL × 10^8.
The findings indicated that the incorporation of 3% TiF4 into MTA demonstrated
the most pronounced antibacterial effectiveness on both day 1 and day 7, with
notable variations observed among the different groups.
Author
(s) Details
Poojitha
Suganthakumar
Conservative Dentistry and Endodontics, SRM Kattankulathur Dental
College and Hospital, SRM Institute of Science and Technology (SRMIST),
Chengalpattu, India.
Tripuravaram
Vinay Kumar Reddy
Conservative Dentistry and Endodontics, SRM Kattankulathur Dental
College and Hospital, SRM Institute of Science and Technology (SRMIST),
Chengalpattu, India.
Vijay
Venkatesh
Conservative Dentistry and Endodontics, SRM Kattankulathur Dental
College and Hospital, SRM Institute of Science and Technology (SRMIST),
Chengalpattu, India.
Kingston
Chellapandian
Conservative Dentistry and Endodontics, SRM Kattankulathur Dental
College and Hospital, SRM Institute
of Science and Technology (SRMIST), Chengalpattu, India.
Mahalakshmi
Krishnan
Department of Microbiology, Sree Balaji Dental College and
Hospital, Chennai, India.
Please see the book here:- https://doi.org/10.9734/bpi/rpmab/v6/1900
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