The present study aimed to assess the changes in salivary profile and its clinical correlation in leukemic (ALL) children undergoing chemotherapy. Chemotherapy adversely affects the salivary glands, altering the quality and quantity of saliva. Several chemotherapeutic agents cause damage to the mucosa which affects the dividing cells of Basal epithelium and also, direct contact of these agents with connective tissues can lead to their extensive damage.
Children who have been diagnosed with Acute Lymphoblastic
Leukaemia undergoing chemotherapy in Bharati Hospital, Pune were included in
the study. Those children were included who fulfilled the following inclusion
and exclusion criteria. Stimulated salivary samples were collected in sterile
vials at 1-, 3-, and 6-month intervals and were assessed for salivary pH and
buffering capacity. Caries and oral manifestations were also checked at each
interval. A total of 25 children with
ALL undergoing chemotherapy were included to participate in the study. The
results were analysed using Statistical Package for the Social Sciences software.
All the major changes were seen in the 1st month, that is, the induction phase
of chemotherapy. Hence, we can say this is the most affected phase of
chemotherapy. Mucositis was more common in the prepubertal age group than the
younger age group in the present study. Also, it was more common in girls than
boys. Given that parents and kids should be motivated to practice good dental
hygiene, this study has clinical significance. To prevent difficulties later
on, all preventive dental procedures should be completed as soon as feasible
before starting chemotherapy.
Author (s) Details
Madhura N Paranjap
Department of Pediatric and Preventive Dentistry, Bharati Vidyapeeth Dental
College and Hospital, Bharati
Vidyapeeth (Deemed to be University), Pune, Maharashtra, India.
Preetam Shah
Department of Pediatric and Preventive Dentistry, Bharati Vidyapeeth Dental
College and Hospital, Bharati
Vidyapeeth (Deemed to be University), Pune, Maharashtra, India.
Smita Patil
Department of Pediatric and Preventive Dentistry, Bharati Vidyapeeth Dental
College and Hospital, Bharati Vidyapeeth (Deemed to be University), Pune,
Maharashtra, India.
Rohan Shah
Department of Pediatric and Preventive Dentistry, Bharati Vidyapeeth Dental
College and Hospital, Bharati
Vidyapeeth (Deemed to be University), Pune, Maharashtra, India
Smita Patil
Department of
Pediatric and Preventive Dentistry, Bharati Vidyapeeth Dental College and
Hospital, Bharati Vidyapeeth (Deemed to be University), Pune, Maharashtra,
India.
Laxmi Lakade
Department of Pediatric and Preventive Dentistry, Bharati Vidyapeeth Dental
College and Hospital, Bharati
Vidyapeeth (Deemed to be University), Pune, Maharashtra, India.
Please see the book here:- https://doi.org/10.9734/bpi/dhrni/v4/1667
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