Pharmacogenomics is a revolutionary medical practice in the
contemporary medicine as it helps clarify the impacts of genetic variability on
medicine response, effectiveness, and safety. The field is synergizing genomic
data with clinical decision-making, and thus allows optimization of
pharmacotherapy according to the genetic profile of the individual instead of
the traditional approach of treating everyone with the same strategy, i.e.,
one-size-fits-all. Individual medicine supported by the development of
pharmacogenomics can potentially reduce adverse drug reactions, improve
treatment results, and increase patient compliance and decrease healthcare expenses.
This book discusses the basic concepts of pharmacogenomics
such as genetic polymorphisms in drug-metabolizing enzymes, transporters and
pharmacological targets. It emphasizes the essential clinical applications in
major therapeutic fields like oncology, cardiovascular diseases,
neuropsychiatric disorder, and infectious diseases with special reference to
the biomarker-directed therapy and dose individualization. The importance of
the use of emerging technologies (next-generation sequencing, bioinformatics,
and artificial intelligence) in expediting the pharmacogenomic investigation
and clinical application is also presented.
Also, this book discusses the existing issues that constrain
the overall implementation of pharmacogenomics, such as ethics, population
diversity, regulatory policies, and economical limitations. This work
highlights the critical contribution of pharmacogenomics to the future of drug
development and precision healthcare, giving way to safer, more effective and
patient-centered therapeutic approaches because it provides an integrated
overview of both scientific, clinical and translational views.
Author(s) Details
Dr. Abeer Mansour
Abdel Rasool
Department of Pharmacology and Toxicology, College of Pharmacy, Nineveh
University, Nineveh, Iraq.
Ahmed Ibrahim Younis
Department of Pharmacology and Toxicology, College of Pharmacy, Nineveh
University, Nineveh, Iraq.
Please see the book here :- https://doi.org/10.9734/bpi/mono/978-81-999106-9-0
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