Background: Diseases of the breast constitute a significant
proportion of surgical cases, and frequently, the need arises to distinguish
benign from malignant lesions prior to definitive treatment. So far, Frozen
Section (FS) is the standard technique with a high level of validity. FS is
routinely used by the surgical pathology laboratories for intraoperative
diagnosis. However, intraoperative scrape cytology can be adopted when special
facilities of FS are not available.
Objectives: The primary objective of the study is to perform
scrape cytology of surgically operable breast masses and evaluate its accuracy
in relation to histopathological diagnosis. This study was designed with the
aim of evaluating the diagnostic accuracy and utility of Intraoperative Scrape
Cytology (IOSC) in providing rapid and accurate diagnosis for breast lumps and
to compare its diagnostic yield with that of paraffin sections.
Methods: This cross-sectional descriptive study was carried
out in the Department of Pathology, Chittagong Medical College, in
collaboration with the Department of Surgery of this institution from October
2013 to September 2014. The study was conducted on 123 patients with breast
lumps who underwent operative treatment. Scrapings were taken from each
specimen before formalin fixation and stained by rapid Papanicolaou staining.
In each case, their accuracy was compared to the histopathological diagnosis.
Statistical analysis was done employing the χ2 test.
Results: Out of 123 cases studied, 122 could be correctly
differentiated into benign and malignant tumours with an accuracy rate of
99.19%. Among benign cases, 66 (53.7%) were fibroadenoma and among malignant
cases, all were duct cell carcinoma.
Conclusion: Intraoperative Scrape Cytology (IOSC) is a
simple, accurate, rapid and cost-effective diagnostic tool, not requiring
specific instruments in contrast to frozen section, can be used
intraoperatively for both diagnosis and management of breast lump. In future,
comparative studies evaluating IOSC alongside frozen section and fine-needle
aspiration cytology in different clinical settings would provide deeper insight
into their relative diagnostic effectiveness.
Author(s) Details
Shahe Systa Mosarrat
Department of Pathology, Chittagong Medical College, Chittagong,
Bangladesh.
Md. Zillur Rahman
Department of Pathology, Chittagong Medical College, Chittagong,
Bangladesh.
Shahab Uddin Ahamad
Department of Pathology, Chittagong Medical College, Chittagong,
Bangladesh.
Pradip Bhattacharjee
Department of Pathology, Chittagong Medical College, Chittagong,
Bangladesh.
Sayeeda Nasreen
Department of Pathology, Chittagong Medical College, Chittagong,
Bangladesh.
Ismail Hossain
Department of Pathology, Chittagong Medical College, Chittagong,
Bangladesh.
Md. Didarul Alam
Department of Radiology & Imaging, USTC, Chittagong, Bangladesh.
Please see the book here :- https://doi.org/10.9734/bpi/aodhr/v10/7078
No comments:
Post a Comment