Purpose: The purpose of the study is to enquire about the epidemiological characteristics of carbapenem-resistant Escherichia coli clinically isolated strains, and to provide data support for treatment and prevention.
Methods: Drug susceptibility testing was performed using the
micro-broth dilution method. The drug sensitivity of strains was evaluated
using the Clinical and Laboratory Standards Institute (CLSI, 29th edition M100)
standards. Data statistical analysis was completed by the WHONET 5.6 software.
Results: Over the three years from 2017 to 2019, a total of
1439 strains of carbapenem-resistant Escherichia coli were isolated. Among
them, urine samples accounted for 33.0% and sputum samples accounted for 29.8%,
ranking the top two. Male patients accounted for 57.4%. The number of internal
medicine patients was twice that of surgical patients. Elderly (>60 years)
and adults (18-59 years) accounted for 59.6% and 30.8% respectively. The
isolation rate in provincial capital cities was the highest, reaching 30.92%.
The resistance rates of carbapenem-resistant Escherichia coli to
cephalosporins, amoxicillin/clavulanic acid, piperacillin/tazobactam, and
amikacin were 90.6%, 69.1%, 69.5%, and 22.2% respectively. Among the
MIC50/MIC90 values, Tigecycline had the lowest value of 0.5/1
g/ml, while Piperacillin and Piperacillin/tazobactam had the
highest value of 128/128
g/ml.
Conclusion: Clinically, carbapenem-resistant Escherichia
coli mainly causes urinary and respiratory system infections in the elderly.
There are significant regional differences in their distribution, and they
exhibit a high resistance rate to
-lactam antibiotics. It is worth noting that tigecycline has
lower MIC50 and MIC90 values for this type of resistant Escherichia coli.
Author (s) Details
Wei Zhang
Department of Microbiology, The First Affiliated Hospital of Hebei North
University, Zhangjiakou, Hebei Province, People’s Republic of China and
Clinical Laboratory, State Key Laboratory of Complex Severe and Rare Diseases,
Peking Union Medical College Hospital, Chinese Academy of Medical Science and
Peking Union Medical College, Beijing, People’s Republic of China.
Zhirong Li
Clinical Laboratory, Hebei Provincial Center for Clinical Laboratories, The
Second Hospital of Hebei Medical
University, Shijiazhuang, People’s Republic of China.
Na Wang
Department of Microbiology, The First Affiliated Hospital of Hebei North
University, Zhangjiakou, Hebei Province, People’s Republic of China.
Zhicong Yang
Department of Microbiology, The First Affiliated Hospital of Hebei North
University, Zhangjiakou, Hebei Province, People’s Republic of China.
Jia Li
Department of Microbiology, The First Affiliated Hospital of Hebei North
University, Zhangjiakou, Hebei Province, People’s Republic of China.
Caiqing Li
Department of Microbiology, The First Affiliated Hospital of Hebei North
University, Zhangjiakou, Hebei Province, People’s Republic of China.
Xuying Han
Department of Microbiology, The First Affiliated Hospital of Hebei North
University, Zhangjiakou, Hebei Province, People’s Republic of China.
Jinlu Liu
Department of Microbiology, The First Affiliated Hospital of Hebei North
University, Zhangjiakou, Hebei
Province, People’s Republic of China.
Liping Li
Clinical Laboratory, Zhangjiakou Xuan Gang Hospital, Zhangjiakou, Hebei
Province, People’s Republic of China.
Shuwang Wang
Clinical Laboratory, Zhangjiakou Xuan Gang Hospital, Zhangjiakou, Hebei
Province, People’s Republic of China.
Minghua Zhan
Department of Microbiology, The First Affiliated Hospital of Hebei North
University, Zhangjiakou, Hebei Province,
People’s Republic of China and Clinical Laboratory, Peking University People’s
Hospital, Beijing, People’s Republic of China.
Please see the book here:- https://doi.org/10.9734/bpi/prrat/v7/2282
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