Anticancer Potential and Photocatalytic Efficiency of Phyto-mediated Copper Oxide Nanoparticles | Chapter 2 | Recent Developments in Chemistry and Biochemistry Research Vol. 4

In a straightforward one-pot synthesis method, Moringa oleifera leaf extract was used to create copper oxide nanoparticles or CuO NPs. The prepared state physicochemical properties of CuO NPs were investigated by means of an array of analytical techniques. Finding the highest absorption peak at 293 nm, which was subsequently utilized to compute the band gap energy (3.82 eV), clearly suggests the existence of CuO nanoparticles. Good crystallinity was indicated by the assessed crystalline size of about 21 nm and the d-spacing value of 0.215 nm of the generated CuO NPs. Its extraordinary elemental purity and well-aggregated structure are confirmed by the EDAX spectrum of the generated CuO NPs. Our preparation method worked, as these facts convincingly show. To further evaluate the generated CuO NPs' potential for in vitro anticancer activities, MCF7 and A549 breast and lung cancer cells were employed. Its potential as a formidable cancer-fighting tactic was highlighted by these data, which showed that varying doses of CuO nanoparticles showed significant and proportionate toxicity toward the assessed cell lines. Furthermore, malachite green (MG) and titan yellow (TY) dyes were degraded using the as-prepared CuO NPs under UV light. Present results show that at the 140th and 110th minute, MG and TY, respectively, showed a noticeable degree of degradation of 84.7% and 79.03% in the basic medium. Upon additional examination of the collected data for the reaction kinetic tests, it was determined that the MG and TY dyes' first-order and zero-order kinetics, respectively, were aligned. The generated CuO NPs not only show great potential as a tool for creating new treatments for lung and breast cancer, but they also have the ability to degrade hazardous cationic and anionic dyes.

 

Author (s) Details

 

Poojitha B. Sridhara Setty
Department of Biotechnology, GM Institute of Technology, Davangere – 577 006, Karnataka, India.

 

Shiva Prasad Kollur
School of Physical Sciences, Amrita Vishwa Vidyapeetham, Mysuru Campus, Mysuru – 570 026, Karnataka, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/rdcbr/v4/594