Background: An inadequate thyroid hormone synthesis slows down the body's metabolism and causes a host of crippling symptoms, such as weight gain, weariness, cold sensitivity, and cognitive decline. Hypothyroidism is a common endocrine illness. Hormone replacement medication is the usual treatment for hypothyroidism, but new research indicates that shortages in some micronutrients, including zinc, vitamin A, and magnesium, may be important in the development and course of the condition. Supplementing these micronutrients could be an adjuvant approach in the treatment of thyroid dysfunction because they are necessary to produce thyroid hormones, metabolism, and immunological regulation.
Objective: The purpose of this study is to look at the potential
therapeutic effects of magnesium, zinc and vitamin A supplements on oxidative
stress, inflammatory markers and thyroid function in people with
hypothyroidism. The goal of the study is to ascertain whether treating deficits
in these micronutrients can boost thyroid hormone production, reduce symptoms,
and strengthen the immune system and metabolism in individuals with
hypothyroidism.
Methods: A detailed review of peer-reviewed literature, including
clinical trials, observational studies, and meta-analyses, was conducted to
explore the role of zinc, vitamin A, and magnesium in thyroid health. The
studies selected for review included both placebo-controlled interventions and
observational data on micronutrient supplementation in hypothyroid patients.
Key variables such as serum levels of thyroid hormones (TSH, FT3, FT4),
oxidative stress markers (hs-CRP, MDA), and overall clinical outcomes were
analysed to assess the effects of supplementation.
Results: The review emphasised a constant positive relationship
between better thyroid function and supplementing with zinc, vitamin A, and magnesium.
It has been discovered that taking zinc supplements helps boost thyroid hormone
synthesis by improving free and total thyroxine (T4) levels and improving TSH
regulation. The antioxidant qualities of vitamin A have been found to lower
oxidative stress and stabilise thyroid function; on the other hand, magnesium
supplementation has improved energy metabolism and decreased inflammatory
indicators. Overall, the patients who received these micronutrients showed
changes in the balance of thyroid hormones, reduced inflammation, and improved
metabolic function, all of which point to important therapeutic advantages.
Conclusion: In summary, the results highlight the possible
function of magnesium, zinc, and vitamin A supplements in the treatment of
hypothyroidism. These micronutrients assist in reducing inflammation and
oxidative stress, which are frequently linked to thyroid diseases, in addition
to aiding in the production and control of thyroid hormones. Patients with
hypothyroidism who take these supplements as part of their treatment plan,
especially if they have known deficits, may experience a better quality of life
and more efficient symptom management. It is advised that larger sample sizes
and longer trial lengths be used in future clinical studies to confirm the
effectiveness of this strategy and provide standardized procedures for
micronutrient supplementation in hypothyroid treatment.
Author
(s) Details
Misbah
Arshad
The University of Lahore, Lahore, Pakistan.
Muntaha
Jaffar
The University of Lahore, Lahore, Pakistan.
Farah
Khanum
The University of Lahore, Lahore, Pakistan.
Noor
Fatima
The University of Lahore, Lahore, Pakistan.
Alina
Akbar
The University of Lahore, Lahore, Pakistan.
Ghulam
Rubab
The University of Lahore, Lahore, Pakistan.
Please see the book here:- https://doi.org/10.9734/bpi/crpbs/v9/2585
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