Background: Women with diabetes mellitus have twice the risk of myocardial infarction (MI) than non-diabetic women of the same age group and bearing the risk of MI in a non-diabetic male of the same age.
Aim: The present study aimed to determine the impact of
hysterectomy in women with type 2 diabetes mellitus in premenopausal age, on
the risk of CAD.
Methods: A total of 181 type 2 diabetic women who underwent
exercise treadmill ECG testing in the hospital during a 30 months period were
studied. Based on an arbitrary cut off age of 48 yrs subjects were assigned in
group 1: age < 48 yrs (premenopausal) and group 2: age
48 years
(postmenopausal). Based on exercise treadmill ECG results, they were sub
grouped as without CAD (treadmill ECG test negative) and with CAD (treadmill
ECG test positive).
Results: Age, duration of diabetes, hypertension and CAD
were significantly more in postmenopausal group (p<0.05). Age,
HDL-cholesterol and hysterectomy were significantly (p< 0.05) associated
with premenopausal CAD. In postmenopausal CAD subgroup age, duration of
diabetes, hypertension, HDL-cholesterol, sedentary physical activity and
hysterectomy were significantly higher (p<0.05). In the multivariate
analysis, hysterectomy was strongly associated (OR = 7.73, p = 0.016) with
premenopausal CAD.
Conclusion: The study projects hysterectomy as a high risk
factor for the CAD in premenopausal type 2 diabetics. More information from
prospective long-term clinical trials targeted to answer the questions
regarding the loss of premenopausal protection of CAD in diabetes and the
optimal treatment strategies for both premenopausal diabetic women and CAD will
help to guide therapy in the future.
Author(s) Details:
Basab Ghosh,
Dr. Basab's Diabetes Care, Opposite Ramnagar 3, T G Road Extension, Krishnanagar, Agartala – 799001, India.
Please see the link here: https://stm.bookpi.org/NVMMS-V2/article/view/13803
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